Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7004603 | 0.83 | ALDH1A1 (0.40) | HSD17B10ALDH1A1MAPTKDM4CSRD5A1 | |
| SCHEMBL7006729 | 0.76 | ALOX5 (0.48) | MTNR1ASRD5A2KMT2AMEN1MAPK14 | |
| SCHEMBL7003392 | 0.74 | MAPK14 (0.48) | MTNR1AMTNR1BMAPTKMT2AMEN1 | |
| SCHEMBL7009955 | 0.74 | NPC1 (0.56) | SRD5A2KMT2AMEN1MAPK14NPC1 | |
| SCHEMBL7009822 | 0.72 | HTR2A (0.43) | HSD17B10ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL9352203 | 0.68 | CTSV (0.46) | HSD17B10ALDH1A1MAPTKDM4CSRD5A1 | |
| SCHEMBL11970494 | 0.67 | MAPK14 (0.52) | ALDH1A1MAPTKMT2AMEN1MAPK14 | |
| SCHEMBL7003133 | 0.67 | CA2 (0.44) | MTNR1AMTNR1BALDH1A1KMT2AMEN1 | |
| SCHEMBL12303126 | 0.66 | MAPT (0.57) | ALDH1A1MAPTKMT2AMEN1NPC1 | |
| SCHEMBL13007327 | 0.66 | MTNR1A (0.77) | MTNR1AMTNR1BHSD17B10ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200439-B1 | 1,2-DIHYDRO-1-OXO-PARAZINO(1,2-A) INDOLE DERIVATIVES | NOVUSPHARMA SPA (IT) | 2003-06-25 | — | — | EP | disclosed |