Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.34 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.33 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.33 |
| ▸ | ALB | P02768 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.33 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8743705 | 0.84 | CRBN (0.36) | HTR6CRBNLMNATHRBMTOR | |
| SCHEMBL886978 | 0.81 | LMNA (0.37) | HTR6CRBNLMNATHRBMTOR | |
| SCHEMBL24672711 | 0.78 | CRBN (0.32) | CRBNLMNATHRBMTORMDM2 | |
| SCHEMBL7016019 | 0.76 | L3MBTL1 (0.50) | HTR6CRBNLMNAMAPTMEN1 | |
| SCHEMBL21253512 | 0.75 | KDM4E (0.38) | LMNAMTORTSHRKDM4E | |
| SCHEMBL7015213 | 0.73 | HTR6 (0.35) | HTR6LMNAMEN1KMT2AKDM4E | |
| SCHEMBL12032567 | 0.73 | HTR6 (0.41) | HTR6 | |
| SCHEMBL27952255 | 0.71 | PIK3CB (0.41) | CRBNLMNATHRBMTORMDM2 | |
| SCHEMBL19929 | 0.71 | — | — | |
| SCHEMBL7015200 | 0.70 | ALDH1A1 (0.36) | CRBNMAPTMEN1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0877022-B1 | Sulfonylpyrimidine derivatives with anticancer activity | RUDJER BOSKOVIC INST (HR) | 2003-04-16 | — | — | EP | claimed |
| EP-0877022-A1 | Synthesis of the sulfonylpyrimidine derivatives with anticancer activity | Herbos d.d. (HR) | 1998-11-11 | — | — | EP | claimed |
| WO-2020214336-A9 | SULFUR-HETEROCYCLE EXCHANGE CHEMISTRY AND USES THEREOF | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2020-11-19 | — | — | WO | disclosed |
| WO-2020214336-A2 | SULFUR-HETEROCYCLE EXCHANGE CHEMISTRY AND USES THEREOF | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2020-10-22 | — | — | WO | disclosed |
| EP-0877022-B1 | Sulfonylpyrimidine derivatives with anticancer activity | RUDJER BOSKOVIC INST (HR) | 2003-04-16 | — | — | EP | disclosed |
| EP-0877022-A1 | Synthesis of the sulfonylpyrimidine derivatives with anticancer activity | Herbos d.d. (HR) | 1998-11-11 | — | — | EP | disclosed |