Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7013283 | 0.91 | HTT (0.40) | POLBTDP1MAPTHTTNPSR1 | |
| SCHEMBL7019042 | 0.83 | KAT2B (0.46) | POLBMAPTKDM4EHTTNPSR1 | |
| SCHEMBL7015497 | 0.82 | MAPT (0.42) | CCR2POLBTDP1MAPTKDM4E | |
| SCHEMBL7010725 | 0.80 | NPC1 (0.42) | MAPTHTTALDH1A1LMNANPC1 | |
| SCHEMBL7016172 | 0.79 | HDAC3 (0.44) | POLBTDP1L3MBTL1MAPTCYP19A1 | |
| SCHEMBL7020546 | 0.77 | MAPT (0.41) | POLBMAPTKDM4EHTTALDH1A1 | |
| SCHEMBL7008568 | 0.71 | PKM (0.41) | TDP1MAPTHTTALDH1A1LMNA | |
| SCHEMBL7016038 | 0.70 | SMN1; SMN2 (0.43) | POLBTDP1L3MBTL1MAPTHTT | |
| SCHEMBL7019092 | 0.70 | MAPT (0.41) | POLBTDP1MAPTKDM4EHTT | |
| SCHEMBL7010653 | 0.69 | PKM (0.45) | POLBTDP1MAPTKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |