Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 2/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | BPTF | Q12830 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | VNN1 | O95497 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7013283 | 0.91 | HTT (0.40) | BRD4HTTNPSR1MITFBPTF | |
| SCHEMBL7010725 | 0.89 | NPC1 (0.42) | HTTRAB9APKMMAPTALDH1A1 | |
| SCHEMBL7015600 | 0.85 | MAPT (0.43) | KAT2BBRD4MAPTLMNAPOLB | |
| SCHEMBL7015497 | 0.83 | MAPT (0.42) | RAB9AMAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7018161 | 0.83 | CCR2 (0.39) | BRD4HTTNPSR1RAB9ABPTF | |
| SCHEMBL7020546 | 0.77 | MAPT (0.41) | HTTMAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7016067 | 0.76 | HDAC3 (0.47) | KAT2BBRD4HTTNPSR1RAB9A | |
| SCHEMBL7018851 | 0.74 | PPARG (0.41) | HTTRAB9APKMMAPTALDH1A1 | |
| SCHEMBL7017131 | 0.72 | CYP19A1 (0.44) | RAB9AMAPTNPC1VNN1TP53 | |
| SCHEMBL7008568 | 0.70 | PKM (0.41) | HTTPKMMITFMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |