Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPD | P32754 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7020546 | 0.89 | MAPT (0.41) | MAPTCNR2MEN1POLBKMT2A | |
| SCHEMBL7015497 | 0.87 | MAPT (0.42) | MAPTRAB9ASRD5A2CNR2MEN1 | |
| SCHEMBL7015600 | 0.82 | MAPT (0.43) | MAPTMEN1POLBKMT2AKDM4E | |
| SCHEMBL7017131 | 0.80 | CYP19A1 (0.44) | MAPTRAB9AMEN1KMT2AHDAC1 | |
| SCHEMBL7018851 | 0.79 | PPARG (0.41) | MAPTRAB9ASRD5A2HDAC1HDAC8 | |
| SCHEMBL7017139 | 0.78 | MAPT (0.42) | MAPTRAB9ASRD5A2MEN1POLB | |
| SCHEMBL7013283 | 0.75 | HTT (0.40) | MAPTMEN1POLBKMT2ATDP1 | |
| SCHEMBL7008568 | 0.70 | PKM (0.41) | MAPTTDP1TP53SMN1; SMN2HTT | |
| SCHEMBL7018161 | 0.70 | CCR2 (0.39) | MAPTRAB9ACNR2MEN1POLB | |
| SCHEMBL7019042 | 0.69 | KAT2B (0.46) | MAPTRAB9AMEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |