Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 7/20 | 0.35 |
| ▸ | JAK1 | P23458 | 6/20 | 0.35 |
| ▸ | TYK2 | P29597 | 6/20 | 0.35 |
| ▸ | JAK2 | O60674 | 6/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | TTK | P33981 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7019103 | 0.73 | ALDH1A1 (0.49) | JAK3JAK1TYK2JAK2MAPT | |
| SCHEMBL7018141 | 0.69 | MAPK1 (0.40) | JAK2ADORA2AADORA1MAPTNPSR1 | |
| SCHEMBL13257531 | 0.69 | LMNA (0.44) | ADORA2AADORA1LMNA | |
| SCHEMBL7010831 | 0.67 | ALDH1A1 (0.42) | ADORA2AADORA1NPSR1 | |
| SCHEMBL13258438 | 0.64 | LMNA (0.40) | ADORA2AADORA1MAPTLMNA | |
| SCHEMBL13266358 | 0.61 | LMNA (0.45) | MAPTLMNA | |
| SCHEMBL28907542 | 0.61 | JAK3 (0.43) | JAK3JAK1JAK2ADORA2AADORA1 | |
| SCHEMBL2564399 | 0.61 | FADS1 (0.48) | MAPTLMNA | |
| SCHEMBL7015802 | 0.60 | NEK1 (0.39) | JAK3JAK1TYK2JAK2ADORA2A | |
| SCHEMBL13257642 | 0.59 | PDE7A (0.51) | MAPTNPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |