Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2B6 | P20813 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 8/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.39 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LYPLA2 | O95372 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2127685 | 0.81 | CYP2B6 (0.50) | CYP2B6CHRM3CYP2D6CHRM2CHRM1 | |
| SCHEMBL2128439 | 0.81 | CYP2B6 (0.50) | CYP2B6CHRM3CYP2D6CHRM2CHRM1 | |
| SCHEMBL327106 | 0.80 | CYP2B6 (0.45) | CYP2B6CHRM3CYP2D6CHRM2CHRM1 | |
| SCHEMBL23721584 | 0.79 | MEN1 (0.40) | CYP2B6CHRM3ALDH1A1KMT2AKDM4E | |
| SCHEMBL7126061 | 0.77 | CYP2B6 (0.45) | CYP2B6CHRM3CYP2D6CHRM2CHRM1 | |
| SCHEMBL23721510 | 0.74 | L3MBTL1 (0.36) | LMNAALDH1A1KMT2ACYP3A4TDP1 | |
| SCHEMBL18112743 | 0.74 | CYP2B6 (0.41) | CYP2B6CHRM3CYP2D6CHRM2CHRM1 | |
| SCHEMBL8330192 | 0.72 | HTT (0.44) | CYP2B6LMNATSHRALDH1A1KMT2A | |
| SCHEMBL2125962 | 0.71 | CHRM3 (0.48) | CHRM3CYP2D6CHRM2CHRM1KCNH2 | |
| SCHEMBL2126336 | 0.71 | CHRM3 (0.48) | CHRM3CYP2D6CHRM2CHRM1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124766-B2 | Inhibitors of diacylglycerol acyltransferase | MADRIGAL PHARMACEUTICALS, INC. (US) | 2012-02-28 | — | — | US | claimed |
| US-20100145047-A1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | MADRIGAL PHARMACEUTICALS, INC. | 2010-06-10 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100145047-A1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | DGAT2, DGAT1, LCAT | CYP2B6 965/4885CHRM3 4708/4885CYP2D6 896/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.