Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aminopyrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.71 |
| ▸ | THRB | P10828 | 2/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | BCHE | P06276 | 5/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aminopyrine SCHEMBL26293 | 0.84 | ALOX15 (1.00) | ALOX15THRBLMNACYP1A2TSHR | |
| Aminopyrine SCHEMBL10489978 | 0.84 | ALOX15 (1.00) | ALOX15THRBLMNACYP1A2TSHR | |
| Aminopyrine SCHEMBL1331641 | 0.84 | ALOX15 (1.00) | ALOX15THRBLMNACYP1A2TSHR | |
| Aminopyrine SCHEMBL2818734 | 0.83 | ALOX15 (0.97) | ALOX15THRBLMNACYP1A2TSHR | |
| Aminopyrine SCHEMBL28152267 | 0.78 | ALOX15 (0.85) | ALOX15THRBLMNACYP1A2TSHR | |
| Aminopyrine SCHEMBL8723416 | 0.78 | ALOX15 (0.85) | ALOX15THRBLMNACYP1A2TSHR | |
| SCHEMBL29651223 | 0.76 | ALOX15 (0.63) | ALOX15THRBLMNACYP1A2TSHR | |
| Propyphenazone SCHEMBL28086369 | 0.76 | LMNA (0.81) | ALOX15THRBLMNACYP1A2TSHR | |
| Aminopyrine SCHEMBL10493337 | 0.76 | ALOX15 (0.81) | ALOX15THRBLMNACYP1A2TSHR | |
| SCHEMBL12112151 | 0.75 | ALDH1A1 (0.81) | LMNATSHRKDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294366-A1 | PHARMACEUTICAL COMPOUNDS FOR TREATING COPD | AstraZeneca AB (SE) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001085146-A1 | PHARMACEUTICAL COMPOUNDS FOR TREATING COPD | ASTRAZENECA AB (SE) | 2001-11-15 | — | — | WO | disclosed |