Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 10/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.36 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.36 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.36 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7045704 | 0.87 | SOAT2 (0.35) | CACNA1BADORA3SOAT2SOAT1CACNA1F | |
| Bromide SCHEMBL7044582 | 0.86 | PPARG (0.46) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| Bromide SCHEMBL7041639 | 0.86 | PPARG (0.46) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| Bromide SCHEMBL7044895 | 0.86 | PPARG (0.46) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| Bromide SCHEMBL7047729 | 0.73 | ADORA3 (0.52) | ADORA3CACNA1DKDM4EGAA | |
| SCHEMBL7044561 | 0.71 | ALDH1A1 (0.51) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7048693 | 0.71 | ALDH1A1 (0.51) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL15869137 | 0.71 | LMNA (0.53) | SOAT2SOAT1KDM4EPPARG | |
| Bromide SCHEMBL7046534 | 0.71 | KDM4E (0.46) | CACNA1FCACNA1DCACNA1SCACNA1CKDM4E | |
| SCHEMBL30211175 | 0.70 | LMNA (0.54) | SOAT2SOAT1KDM4EPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030064954-A1 | Cationic amphiphilic 1,4-dihydropyridine derivatives useful for delivery of nucleotide containing compounds | SPONDULI SERVICES, LTD. (AU) | 2003-04-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030064954-A1 | Cationic amphiphilic 1,4-dihydropyridine derivatives useful for delivery of nucleotide containing compounds | ACIN1, DNA2, KPNA1 | CACNA1B 1089/4885ADORA3 278/4885SOAT2 1325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.