Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | LGMN | Q99538 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HPD | P32754 | 2/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7059284 | 0.85 | PTGS1 (0.34) | SMN1; SMN2PKMRAB9AADORA2BALDH1A1 | |
| SCHEMBL6679666 | 0.83 | MTHFD2 (0.38) | PKMRAB9AALDH1A1LMNAMAPT | |
| SCHEMBL7118303 | 0.83 | L3MBTL1 (0.41) | SMN1; SMN2PKMRAB9AALDH1A1LMNA | |
| SCHEMBL7121978 | 0.83 | TRPA1 (0.50) | SMN1; SMN2ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL7118476 | 0.81 | MMP1 (0.43) | SMN1; SMN2ADORA3ADORA2BALDH1A1MAPT | |
| SCHEMBL7120749 | 0.80 | MAPT (0.46) | SMN1; SMN2RAB9AALDH1A1MAPTHPGD | |
| SCHEMBL7061898 | 0.75 | GAA (0.47) | SMN1; SMN2PKMRAB9ALGMNADORA3 | |
| SCHEMBL6678512 | 0.74 | SMN1; SMN2 (0.45) | SMN1; SMN2PKMRAB9ALGMNADORA3 | |
| SCHEMBL7123266 | 0.72 | KDM4E (0.39) | PKMALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL7114826 | 0.72 | TRPA1 (0.40) | SMN1; SMN2ALDH1A1LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040224951-A1 | 5,6-Fused uracil derivatives as matrix metalloproteinase inhibitors | ROARK WILLIAM HOWARD (US) | 2004-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040224951-A1 | 5,6-Fused uracil derivatives as matrix metalloproteinase inhibitors | MMP9, MMP13, MMP25 | SMN1; SMN2 682/4885PKM 2081/4885RAB9A 627/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.