SCHEMBL7062249

SCHEMBL7062249

C#CCOC(=O)n1cc(F)c(N)nc1=O

nearest known ligand 0.35

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ALB P02768 1/20 0.35
EP300 Q09472 4/20 0.35
NPC1 O15118 1/20 0.33
CA12 O43570 1/20 0.31
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA9 Q16790 1/20 0.31
CA14 Q9ULX7 1/20 0.31
GSTP1 P09211 1/20 0.31
PKM P14618 1/20 0.31
POLG P54098 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1224879 0.84 EP300 (0.46) ALBEP300
SCHEMBL12883799 0.80 EP300 (0.39) ALBEP300POLG
SCHEMBL7122663 0.80 ALDH1A1 (0.35) ALBEP300POLG
SCHEMBL12883801 0.80 ALB (0.34) ALBEP300POLG
SCHEMBL12883796 0.78 EP300 (0.36) ALBEP300
SCHEMBL12883793 0.78 EP300 (0.38) ALBEP300
SCHEMBL2470522 0.77 LMNA (0.39) EP300NPC1
SCHEMBL1223628 0.77 KDM4E (0.41) NPC1
SCHEMBL7064563 0.76 EP300 (0.41) EP300NPC1
SCHEMBL12883788 0.76 POLB (0.40) PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030166606-A1 5'-deoxy-n-(substituted oxycarbonyl)-5-fluorocytosine and derivatives thereof, method of preparing same, and anticancer composition comprising same as active ingredients KOLON INDUSTRIES, INC. (KR) 2003-09-04 US disclosed
EP-1311524-A2 5'-DEOXY-N-(SUBSTITUTED OXYCARBONYL)-5-FLUOROCYTOSINE AND DERIVATIVES THEREOF, METHOD OF PREPARING SAME, AND ANTICANCER COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENTS Kolon Industries, Inc. (KR) 2003-05-21 EP disclosed
WO-2002011668-A2 5'-DEOXY-N-(SUBSTITUTED OXYCARBONYL)-5-FLUOROCYTOSINE AND DERIVATIVES THEREOF, METHOD OF PREPARING SAME, AND ANTICANCER COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENTS KOLON INDUSTRIES, INC. (KR) 2002-02-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030166606-A1 5'-deoxy-n-(substituted oxycarbonyl)-5-fluorocytosine and derivatives thereof, method of preparing same, and anticancer composition comprising same as active ingredients DUT, RNGTT, MTAP ALB 1195/4885EP300 3927/4885NPC1 816/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.