Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | F10 | P00742 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PLG | P00747 | 3/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7074868 | 0.89 | KMT2A (0.52) | KMT2AMEN1PKMMAPK1ALDH1A1 | |
| SCHEMBL7077118 | 0.85 | ALDH1A1 (0.52) | PKMALDH1A1POLBGAAPLG | |
| SCHEMBL7071442 | 0.81 | SMN1; SMN2 (0.56) | PKMALDH1A1MAPTGAAPLG | |
| SCHEMBL7074294 | 0.81 | ALDH1A1 (0.54) | KMT2AMEN1PKMF10ALDH1A1 | |
| SCHEMBL7074309 | 0.81 | PKM (0.63) | KMT2APKMF10ALDH1A1GAA | |
| SCHEMBL7651893 | 0.81 | KMT2A (0.53) | KMT2AMEN1PKMMAPK1ALDH1A1 | |
| SCHEMBL7073640 | 0.80 | PLG (0.56) | KMT2APKMF10ALDH1A1POLB | |
| SCHEMBL7074609 | 0.80 | PLG (0.66) | KMT2AMEN1PKMF10ALDH1A1 | |
| SCHEMBL7074560 | 0.79 | PLG (0.57) | F10ALDH1A1POLBPLGF2 | |
| SCHEMBL7074612 | 0.77 | PLG (0.56) | KMT2AMEN1PKMF10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-6492368-B1 | Benzamidine derivatives as factor XA inhibitors | MERCK PATENT GMBH (DE) | 2002-12-10 | — | — | US | disclosed |