Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | FPR2 | P25090 | 6/20 | 0.44 |
| ▸ | PROKR1 | Q8TCW9 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7072218 | 0.83 | SCN9A (0.53) | HDAC4HDAC2HDAC8HDAC6MGLL | |
| SCHEMBL7071746 | 0.81 | MEN1 (0.54) | MGLLALDH1A1LMNA | |
| SCHEMBL7076839 | 0.81 | KMT2A (0.59) | HDAC4HDAC2HDAC8HDAC6MGLL | |
| SCHEMBL7075149 | 0.80 | PROKR1 (0.48) | THRBFPR2PROKR1MAPTMET | |
| Acetic Acid SCHEMBL27550415 | 0.80 | PROKR1 (0.46) | THRBFPR2PROKR1MAPTMET | |
| SCHEMBL7074664 | 0.80 | THRB (0.53) | MGLLTHRBMAPTALDH1A1LMNA | |
| SCHEMBL7069359 | 0.80 | THRB (0.48) | MGLLTHRBALDH1A1LMNA | |
| SCHEMBL7075338 | 0.80 | THRB (0.58) | HDAC4HDAC2HDAC8HDAC6MGLL | |
| SCHEMBL7075196 | 0.79 | MGLL (0.54) | HDAC4HDAC2HDAC8HDAC6MGLL | |
| SCHEMBL7074222 | 0.79 | LMNA (0.62) | MGLLTHRBALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-6492368-B1 | Benzamidine derivatives as factor XA inhibitors | MERCK PATENT GMBH (DE) | 2002-12-10 | — | — | US | disclosed |