Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | SLC6A7 | Q99884 | 3/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | FASN | P49327 | 1/20 | 0.54 |
| ▸ | PLK1 | P53350 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7070548 | 0.90 | MGLL (0.56) | MGLLMAPK1MAPTMEN1KMT2A | |
| SCHEMBL7071582 | 0.89 | LMNA (0.60) | MGLLMEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL7076687 | 0.88 | TSHR (0.59) | MGLLPOLBHDAC4HPGDHDAC6 | |
| SCHEMBL7649408 | 0.87 | DGAT1 (0.58) | MGLLPOLBHDAC4MAPTPLK1 | |
| SCHEMBL7075122 | 0.86 | LMNA (0.65) | MGLLHDAC4TSHRALDH1A1LMNA | |
| SCHEMBL7071696 | 0.85 | ALDH1A1 (0.61) | MGLLPOLBHDAC4HDAC6HDAC2 | |
| SCHEMBL7075403 | 0.84 | ALDH1A1 (0.57) | MGLLPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL7074159 | 0.84 | MGLL (0.55) | MGLLPOLBHDAC4MAPK1HDAC6 | |
| SCHEMBL3099478 | 0.84 | MGLL (0.55) | MGLLHDAC4HDAC6HDAC2HDAC8 | |
| SCHEMBL7075196 | 0.84 | MGLL (0.54) | MGLLHDAC4MAPK1HDAC6HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-6492368-B1 | Benzamidine derivatives as factor XA inhibitors | MERCK PATENT GMBH (DE) | 2002-12-10 | — | — | US | disclosed |