Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 11/20 | 0.67 |
| ▸ | MMP12 | P39900 | 10/20 | 0.67 |
| ▸ | MMP9 | P14780 | 10/20 | 0.67 |
| ▸ | MMP14 | P50281 | 8/20 | 0.67 |
| ▸ | MMP8 | P22894 | 8/20 | 0.67 |
| ▸ | MMP13 | P45452 | 8/20 | 0.67 |
| ▸ | MMP16 | P51512 | 7/20 | 0.67 |
| ▸ | MMP1 | P03956 | 6/20 | 0.67 |
| ▸ | MMP3 | P08254 | 5/20 | 0.67 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | BMP1 | P13497 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7072859 | 0.86 | MMP2 (0.64) | MMP2MMP12MMP9MMP14MMP8 | |
| SCHEMBL7072106 | 0.79 | MMP13 (0.64) | MMP2MMP12MMP9MMP14MMP8 | |
| SCHEMBL7076489 | 0.77 | MMP12 (0.68) | MMP2MMP12MMP9MMP14MMP8 | |
| SCHEMBL7077625 | 0.77 | L3MBTL1 (0.51) | MMP2MMP12MMP14MMP8MMP13 | |
| SCHEMBL7073806 | 0.76 | CA1 (0.52) | MMP2MMP12MMP9MMP14MMP8 | |
| SCHEMBL7072073 | 0.75 | PGR (0.57) | MMP2MMP12MMP9MMP14MMP8 | |
| SCHEMBL7076487 | 0.72 | PGR (0.50) | L3MBTL1KMT2AMEN1PGRMAPT | |
| SCHEMBL7076512 | 0.71 | MMP9 (0.53) | MMP2MMP12MMP9MMP14MMP8 | |
| SCHEMBL11506755 | 0.70 | LMNA (0.52) | L3MBTL1KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL10186886 | 0.69 | L3MBTL1 (0.83) | L3MBTL1KMT2AMEN1PGRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030022893-A1 | Hydroxamic and carboxylic acid derivatives | BAXTER ANDREW DOUGLAS (GB) | 2003-01-30 | — | — | US | claimed |
| US-6465468-B1 | SUCH AS N-HYDROXY-2-(4-(4-CHLOROPHENYL)PIPERAZINE-1-SULFONYL)BENZAMIDE; INHIBITORS OF MATRIX METALLOPROTEINASE, ADAM OR ADAMTS ENZYMES; TREATMENT OF DEGENERATIVE DISEASES AND CERTAIN CANCERS | DARWIN DISCOVERY LIMITED (GB) | 2002-10-15 | — | — | US | claimed |
| US-20030022893-A1 | Hydroxamic and carboxylic acid derivatives | BAXTER ANDREW DOUGLAS (GB) | 2003-01-30 | — | — | US | disclosed |
| US-6465468-B1 | SUCH AS N-HYDROXY-2-(4-(4-CHLOROPHENYL)PIPERAZINE-1-SULFONYL)BENZAMIDE; INHIBITORS OF MATRIX METALLOPROTEINASE, ADAM OR ADAMTS ENZYMES; TREATMENT OF DEGENERATIVE DISEASES AND CERTAIN CANCERS | DARWIN DISCOVERY LIMITED (GB) | 2002-10-15 | — | — | US | disclosed |
| EP-1163213-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES | Darwin Discovery Limited (GB) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000056704-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES | DARWIN DISCOVERY LIMITED (GB) | 2000-09-28 | — | — | WO | disclosed |