Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 13/20 | 0.67 |
| ▸ | RAB9A | P51151 | 13/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | AR | P10275 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.65 |
| ▸ | MAPT | P10636 | 5/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 2/20 | 0.65 |
| ▸ | PKM | P14618 | 2/20 | 0.65 |
| ▸ | GMNN | O75496 | 1/20 | 0.65 |
| ▸ | THPO | P40225 | 1/20 | 0.65 |
| ▸ | BLM | P54132 | 1/20 | 0.65 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30644241 | 1.00 | NPC1 (0.67) | NPC1RAB9AMEN1KMT2AAR | |
| SCHEMBL26826802 | 0.98 | NPC1 (0.65) | NPC1RAB9AMEN1KMT2AAR | |
| SCHEMBL12112870 | 0.89 | RAB9A (0.80) | NPC1RAB9AMEN1KMT2AAR | |
| SCHEMBL31571831 | 0.83 | RAB9A (0.71) | NPC1RAB9AMEN1KMT2AAR | |
| SCHEMBL706884 | 0.83 | RAB9A (0.71) | NPC1RAB9AMEN1KMT2AAR | |
| 2-Phenylquinoline SCHEMBL29399739 | 0.83 | RAB9A (0.73) | NPC1RAB9AMEN1KMT2AAR | |
| 2-Phenylquinoline SCHEMBL44999 | 0.83 | RAB9A (0.73) | NPC1RAB9AMEN1KMT2AAR | |
| SCHEMBL26824826 | 0.83 | NPC1 (0.56) | NPC1RAB9AMEN1KMT2AAR | |
| SCHEMBL1924662 | 0.82 | NPC1 (0.56) | NPC1RAB9AMEN1KMT2AAR | |
| 2-Phenylquinoline SCHEMBL6130707 | 0.82 | RAB9A (0.66) | NPC1RAB9AMEN1KMT2AAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111116466-B | Catalytic synthesis method of polysubstituted quinoline derivative | 浙江万里学院 | 2023-02-10 | — | — | CN | claimed |
| US-20230337527-A1 | ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING SAME | LAPTO CO., LTD. (KR) | 2023-10-19 | — | — | US | disclosed |
| US-20230337527-A1 | ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING SAME | LAPTO CO., LTD. (KR) | 2023-10-19 | — | — | US | disclosed |
| CN-111116466-B | Catalytic synthesis method of polysubstituted quinoline derivative | 浙江万里学院 | 2023-02-10 | — | — | CN | disclosed |
| CN-113979956-A | Method for synthesizing 2-arylquinoxaline and 3-arylquinoxaline-2 (1H) -one based on mechanical grinding of aryldiazonium salts | 广西师范大学 | 2022-01-28 | — | — | CN | disclosed |
| CN-111116466-A | Catalytic synthesis method of polysubstituted quinoline derivative | 浙江万里学院 | 2020-05-08 | — | — | CN | disclosed |
| CN-107400084-B | Method for synthesizing quinoline derivative | 南京理工大学 | 2020-04-10 | — | — | CN | disclosed |
| EP-3197900-B1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | MERCK SHARP & DOHME (US) | 2020-02-12 | — | — | EP | disclosed |
| CN-110467568-A | A kind of synthetic method of aryl quinoline derivatives | UNIV WENZHOU | 2019-11-19 | — | — | CN | disclosed |
| CN-106831565-B | The restoring method of benzo aromatic aza cyclics | 三峡大学 | 2019-11-08 | — | — | CN | disclosed |
| US-8053445-B2 | Utilities of olefin derivatives | SHIONOGI & CO., LTD. (JP) | 2011-11-08 | — | — | US | disclosed |
| EP-2217070-A1 | NUCLEIC ACID FLUORESCENT STAINS | Sigma-Aldrich Co. (US) | 2010-08-18 | — | — | EP | disclosed |
| CN-101691354-A | Method for chemically synthesizing 2-heteroaryl substituted quinoline derivatives | UNIV ZHEJIANG TECHNOLOGY | 2010-04-07 | — | — | CN | disclosed |
| US-20100041045-A1 | NUCLEIC ACID FLUORESCENT STAINS | SIGMA-ALDRICH CO. (US) | 2010-02-18 | — | — | US | disclosed |
| WO-2009064943-A1 | NUCLEIC ACID FLUORESCENT STAINS | SIGMA-ALDRICH CO. (US) | 2009-05-22 | — | — | WO | disclosed |
| US-20090131279-A1 | NUCLEIC ACID FLUORESCENT STAINS | SIGMA ALDRICH COMPANY (US) | 2009-05-21 | — | — | US | disclosed |
| US-20090036457-A1 | Utilities of olefin derivatives | YAMAMORI TERUO | 2009-02-05 | — | — | US | disclosed |
| US-20040242615-A1 | Utilities of olefin derivatives | SHIONOGI & CO., LTD. (JP) | 2004-12-02 | — | — | US | disclosed |
| US-6815447-B2 | 6-N-(2-AMINO-PYRIMIDIN-4-YL)QUINOLINE-6-AMINE DERIVATIVES; ANALGESICS | ASTRAZENECA AB (SE) | 2004-11-09 | — | — | US | disclosed |
| US-5532374-A | Method of preparation of bis-quinolines | HITACHI CHEMICAL COMPANY, LTD. (JP) | 1996-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242615-A1 | Utilities of olefin derivatives | APOL1, NR1H2, APOB | NPC1 19/4885RAB9A 4723/4885MEN1 3997/4885 |
| US-20230337527-A1 | ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING SAME | AOC1, ODC1, PIEZO1 | NPC1 1199/4885RAB9A 3157/4885MEN1 1661/4885 |
| US-20090131279-A1 | NUCLEIC ACID FLUORESCENT STAINS | POLRMT, HNRNPH3, EWSR1 | NPC1 1437/4885RAB9A 4009/4885MEN1 3100/4885 |
| US-20090036457-A1 | Utilities of olefin derivatives | APOL1, APOB, NR1H2 | NPC1 48/4885RAB9A 4606/4885MEN1 3163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.