Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8566029 | 0.71 | LMNA (0.52) | ALDH1A1CYP2D6OPRM1OPRK1OPRL1 | |
| SCHEMBL844128 | 0.71 | LMNA (0.52) | ALDH1A1CYP2D6OPRM1OPRK1OPRL1 | |
| SCHEMBL4673678 | 0.71 | LMNA (0.52) | ALDH1A1CYP2D6OPRM1OPRK1OPRL1 | |
| SCHEMBL8564803 | 0.71 | LMNA (0.52) | ALDH1A1CYP2D6OPRM1OPRK1OPRL1 | |
| SCHEMBL4671814 | 0.68 | CHRM2 (0.39) | ALDH1A1CYP2D6KMT2AOPRM1OPRD1 | |
| SCHEMBL4675500 | 0.68 | CHRM2 (0.39) | ALDH1A1CYP2D6KMT2AOPRM1OPRD1 | |
| SCHEMBL4726066 | 0.68 | CYP2D6 (0.43) | ALDH1A1CYP2D6HSD11B1KMT2AMEN1 | |
| SCHEMBL28219758 | 0.68 | CYP2D6 (0.47) | ALDH1A1CYP2D6HSD11B1OPRM1OPRD1 | |
| SCHEMBL21966086 | 0.68 | OPRD1 (0.36) | ALDH1A1CYP2D6KMT2AMEN1OPRD1 | |
| SCHEMBL844723 | 0.68 | OPRM1 (0.42) | ALDH1A1CYP2D6KMT2AOPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030236279-A1 | Substituted-aryl compounds for treatment of disease | PHARMACIA & UPJOHN COMPANY | 2003-12-25 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030236279-A1 | Substituted-aryl compounds for treatment of disease | NAT1, CYP7A1, CYP7B1 | ALDH1A1 87/4885CYP2D6 27/4885HSD11B1 58/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.