Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.42 |
| ▸ | PRKCG | P05129 | 2/20 | 0.42 |
| ▸ | PRKCB | P05771 | 2/20 | 0.42 |
| ▸ | PRKCA | P17252 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.32 |
| ▸ | MYLK | Q15746 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | WEE1 | P30291 | 1/20 | 0.31 |
| ▸ | DHFR | P00374 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3775971 | 0.84 | GSK3B (0.61) | GSK3BPRKCGPRKCBPRKCAMAPT | |
| SCHEMBL27502730 | 0.76 | PRKCG (0.39) | GSK3BPRKCGPRKCBPRKCAMAPT | |
| SCHEMBL5756702 | 0.76 | GSK3B (0.71) | GSK3BPRKCGPRKCBPRKCAMYLK | |
| SCHEMBL3777462 | 0.73 | GSK3B (0.53) | GSK3BPRKCGPRKCBPRKCAMAPT | |
| SCHEMBL5758532 | 0.70 | PRKCA (0.84) | GSK3BPRKCGPRKCBPRKCAMAPT | |
| SCHEMBL3771589 | 0.67 | PRKCA (0.84) | GSK3BPRKCGPRKCBPRKCA | |
| SCHEMBL27502732 | 0.66 | MYLK (0.37) | GSK3BPRKCAMAPTDNM1MYLK | |
| SCHEMBL5755763 | 0.66 | GSK3B (0.64) | GSK3BPRKCGPRKCBPRKCA | |
| SCHEMBL5757611 | 0.64 | GSK3B (0.59) | GSK3BPRKCGPRKCBPRKCA | |
| SCHEMBL13013286 | 0.62 | AKR1B1 (0.40) | MAPTDNM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362047-A2 | INDAZOLYL-SUBSTITUTED PYRROLINE COMPOUNDS AS KINASE INHIBITORS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002046183-A2 | INDAZOLYL-SUBSTITUTED PYRROLINE COMPOUNDS AS KINASE INHIBITORS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2002-06-13 | — | — | WO | disclosed |