Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.60 |
| ▸ | HTR6 | P50406 | 7/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.46 |
| ▸ | NQO2 | P16083 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | PPARD | Q03181 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6830010 | 0.85 | ADRB2 (0.58) | ADRB2HTR6MTNR1AMTNR1BNQO2 | |
| SCHEMBL25344812 | 0.84 | HTR6 (0.47) | ADRB2HTR6MTNR1AMTNR1BNQO2 | |
| SCHEMBL28310240 | 0.83 | ADRB2 (0.65) | ADRB2HTR6MTNR1AMTNR1BNQO2 | |
| SCHEMBL27343727 | 0.82 | ADRB2 (0.72) | ADRB2HTR6MTNR1AMTNR1BNQO2 | |
| SCHEMBL1320472 | 0.79 | HTR1D (0.35) | ADRB2HTR6HTR1AHTR1DHTR1B | |
| SCHEMBL1971963 | 0.78 | MTNR1A (0.72) | ADRB2HTR6MTNR1AMTNR1BNQO2 | |
| SCHEMBL29194213 | 0.77 | ADRB2 (0.72) | ADRB2HTR6MTNR1AMTNR1BNQO2 | |
| SCHEMBL28121087 | 0.76 | ADRB2 (0.67) | ADRB2HTR6MTNR1AMTNR1BNQO2 | |
| Oxalic Acid SCHEMBL27614859 | 0.76 | ADRB2 (0.62) | ADRB2HTR6MTNR1AMTNR1BNQO2 | |
| SCHEMBL1130016 | 0.75 | ADRB2 (1.00) | ADRB2HTR6MTNR1AMTNR1BNQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030114512-A1 | Compounds with 5-ht2 and 5-ht1a agonist activity for treating glaucoma | ALCON UNIVERSAL LTD. (CH) | 2003-06-19 | — | — | US | disclosed |
| EP-1263434-A1 | COMPOUNDS WITH 5-HT 2 AND 5-HT 1A AGONIST ACTIVITY FOR TREATING GLAUCOMA | Alcon, Inc (CH) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001070223-A1 | COMPOUNDS WITH 5-HT2 AND 5-HT1A AGONIST ACTIVITY FOR TREATING GLAUCOMA | ALCON, INC. (CH) | 2001-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030114512-A1 | Compounds with 5-ht2 and 5-ht1a agonist activity for treating glaucoma | HTR1A, HTR2A, HTR5A | ADRB2 27/4885HTR6 16/4885MTNR1A 39/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.