Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 8/20 | 0.59 |
| ▸ | ABCC8 | Q09428 | 8/20 | 0.59 |
| ▸ | KCNJ11 | Q14654 | 8/20 | 0.59 |
| ▸ | KCNJ8 | Q15842 | 8/20 | 0.59 |
| ▸ | BRD4 | O60885 | 6/20 | 0.46 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.38 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13014236 | 0.77 | BRD4 (0.59) | ABCC9ABCC8KCNJ11KCNJ8BRD4 | |
| SCHEMBL7006023 | 0.75 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7100558 | 0.73 | PKM (0.49) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7098441 | 0.72 | ABCC9 (0.78) | ABCC9ABCC8KCNJ11KCNJ8MEN1 | |
| SCHEMBL7095756 | 0.68 | ABCC9 (0.58) | ABCC9ABCC8KCNJ11KCNJ8BRD4 | |
| SCHEMBL7814667 | 0.68 | MAPT (0.73) | MEN1LMNAMAPTMAPK1KMT2A | |
| SCHEMBL7817258 | 0.67 | GPR174 (0.72) | ABCC9ABCC8KCNJ11KCNJ8MEN1 | |
| SCHEMBL7096267 | 0.67 | LMNA (0.53) | ABCC9KCNJ11BRD4BRDTMEN1 | |
| SCHEMBL7343713 | 0.67 | MAPT (0.48) | MEN1LMNAMAPTMAPK1KMT2A | |
| SCHEMBL13302833 | 0.66 | ALDH1A1 (0.46) | MEN1LMNAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1278746-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | Abbott Laboratories (US) | 2003-01-29 | — | — | EP | claimed |
| WO-2001083480-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-11-08 | — | — | WO | claimed |
| EP-1131322-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-09-12 | — | — | EP | claimed |
| WO-2000024741-A2 | DIHYDROPYRIDINE COMPOUNDS AND THEIR USE AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2000-05-04 | — | — | WO | claimed |
| EP-1278746-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | Abbott Laboratories (US) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001083480-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-11-08 | — | — | WO | disclosed |
| EP-1131322-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000024741-A2 | DIHYDROPYRIDINE COMPOUNDS AND THEIR USE AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2000-05-04 | — | — | WO | disclosed |