Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | CES1 | P23141 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2127486 | 0.81 | CES1 (0.43) | TDP1CES1CYP3A4MAPTKDM4E | |
| SCHEMBL186246 | 0.80 | LMNA (0.52) | TDP1CES1CYP3A4MAPTKDM4E | |
| SCHEMBL4828715 | 0.79 | CES1 (0.42) | TDP1CES1CYP3A4MAPTKDM4E | |
| SCHEMBL2762547 | 0.78 | LMNA (0.50) | TDP1CES1CYP3A4MAPTKDM4E | |
| SCHEMBL2762264 | 0.78 | LMNA (0.50) | TDP1CES1CYP3A4MAPTKDM4E | |
| SCHEMBL1816682 | 0.78 | MAPT (0.50) | TDP1CES1CYP3A4MAPTKDM4E | |
| SCHEMBL489956 | 0.76 | MAPT (0.44) | TDP1CES1CYP3A4MAPTKDM4E | |
| SCHEMBL27966805 | 0.75 | CES2 (0.53) | CES1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL29035467 | 0.74 | ELANE (0.51) | TDP1MAPTKDM4EMEN1HPGD | |
| SCHEMBL29234727 | 0.74 | CA2 (0.50) | TDP1CES1CYP3A4MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030125300-A1 | Method and composition for conjugating molecules to nucleic acids | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH | 2003-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030125300-A1 | Method and composition for conjugating molecules to nucleic acids | RNGTT, TARBP1, NSUN3 | TDP1 188/4885CES1 2415/4885CYP3A4 4738/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.