Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5364899 | 0.80 | GPR3 (0.32) | — | |
| Tromethamine SCHEMBL7029632 | 0.74 | MEN1 (0.34) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL7646657 | 0.74 | MEN1 (0.34) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL9193688 | 0.73 | MEN1 (0.42) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL8531348 | 0.69 | MEN1 (0.42) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL7652452 | 0.69 | MEN1 (0.42) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL7196402 | 0.69 | MEN1 (0.42) | MEN1LMNAKMT2A | |
| SCHEMBL13265067 | 0.69 | SHBG (0.34) | — | |
| SCHEMBL18929647 | 0.69 | ACHE (0.33) | — | |
| Tromethamine SCHEMBL2792570 | 0.68 | MEN1 (0.40) | MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889047-B1 | Stabilizer for (fluoroaryl) borane compound and methods of stabilizing and crystallizing (fluoroaryl) borane compound | NIPPON CATALYTIC CHEM IND (JP) | 2003-09-03 | — | — | EP | disclosed |