Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.48 |
| ▸ | CES1 | P23141 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 6/20 | 0.47 |
| ▸ | CA2 | P00918 | 6/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.46 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9770781 | 0.81 | CA2 (0.55) | CES2CES1CA2GSK3BHDAC1 | |
| SCHEMBL22116187 | 0.80 | CES2 (0.57) | CES2CES1CA1CA2GSK3B | |
| SCHEMBL711848 | 0.79 | PLOD2 (0.50) | CES2CES1CA1CA2 | |
| SCHEMBL1398393 | 0.78 | CES1 (0.59) | CES2CES1CA1CA2GSK3B | |
| SCHEMBL9770874 | 0.78 | ALDH1A1 (0.48) | HDAC4HDAC6GAAALDH1A1LMNA | |
| SCHEMBL584064 | 0.77 | CES2 (0.43) | CES2CES1CA1CA2GSK3B | |
| SCHEMBL583454 | 0.77 | CES1 (0.43) | CES2CES1CA1CA2GSK3B | |
| SCHEMBL583437 | 0.77 | CES1 (0.57) | CES2CES1GSK3BPARP1ALDH1A1 | |
| SCHEMBL29035966 | 0.77 | CES2 (0.57) | CES2CES1CA1CA2GSK3B | |
| SCHEMBL9630805 | 0.75 | CES1 (0.55) | CES2CES1GSK3BALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4857475-A | Labelled and labellable reagents for fluorometric assays | Ekins, Roger Philip (GB) | 1989-08-15 | — | — | US | claimed |
| US-4565790-A | LANTHANIDE SERIES COMPLEX, B-DIKETONE, DETERGENT | WALLAC OY (FI) | 1986-01-21 | — | — | US | claimed |
| US-9017962-B2 | Intracellular reporters | THE JOHNS HOPKINS UNIVERSITY (US) | 2015-04-28 | — | — | US | disclosed |
| EP-1943262-B1 | IRE-1 ALPHA SUBSTRATES | MANNKIND CORP (US) | 2013-01-23 | — | — | EP | disclosed |
| US-8252549-B2 | Multi-purpose substrates useful for cell culture and methods for making | CORNING INCORPORATED (US) | 2012-08-28 | — | — | US | disclosed |
| US-8236523-B2 | Camp reporters and high throughput assays | THE JOHNS HOPKINS UNIVERSITY (US) | 2012-08-07 | — | — | US | disclosed |
| US-8124343-B2 | IRE-1α substrates | MANNKIND CORPORATION (US) | 2012-02-28 | — | — | US | disclosed |
| US-8080235-B2 | Protein kinase A reporters useful in high throughput assays | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-12-20 | — | — | US | disclosed |
| WO-2011149743-A1 | MULTIPLY FLUORESCENTLY LABELED CALCIUM PHOSPHATE-PROTEIN SURFACES | CORNING INCORPORATED (US) | 2011-12-01 | — | — | WO | disclosed |
| US-20110287952-A1 | IRE-1alpha SUBSTRATES | MANNKIND CORPORATION (US) | 2011-11-24 | — | — | US | disclosed |
| US-20110275103-A1 | EMISSION RATIOMETRIC REPORTERS OF MEMBRANE PDK1 ACTIVATION | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-11-10 | — | — | US | disclosed |
| US-20080096224-A1 | Emission ratiometric indicators of phosphoinositides | THE JOHNS HOPKINS UNIVERSITY (US) | 2008-04-24 | — | — | US | disclosed |
| EP-1791972-A2 | cAMP REPORTERS | The Johns Hopkins University (US) | 2007-06-06 | — | — | EP | disclosed |
| US-20070111270-A1 | cAMP reporters and high throughput assays | THE JOHNS HOPKINS UNIVERSITY (US) | 2007-05-17 | — | — | US | disclosed |
| US-20070105123-A1 | IRE-1alpha substrates | MANNKIND CORPORATION (US) | 2007-05-10 | — | — | US | disclosed |
| WO-2007053151-A1 | IRE-1α SUBSTRATES | MANNKIND CORPORATION (US) | 2007-05-10 | — | — | WO | disclosed |
| WO-2007050734-A1 | PROTEIN KINASE A REPORTERS USEFUL IN HIGH THROUGHPUT ASSAYS | THE JOHNS HOPKINS UNIVERSITY (US) | 2007-05-03 | — | — | WO | disclosed |
| WO-2006023972-A2 | cAMP REPORTERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2006-03-02 | — | — | WO | disclosed |
| US-20050250171-A1 | Methods and tools for detecting collagen degradation | CAMBREX BIO SCIENCE WALKERSVILLE, INC. (US) | 2005-11-10 | — | — | US | disclosed |
| US-20010055776-A1 | High throughput cell-based assay kits | GREENWALT DALE (US) | 2001-12-27 | — | — | US | disclosed |