Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 11/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.87 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.46 |
| ▸ | KDM4A | O75164 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7106355 | 0.93 | OPRK1 (1.00) | OPRK1OPRD1POLBMMP8CYP2C9 | |
| SCHEMBL7102313 | 0.86 | OPRK1 (1.00) | OPRK1OPRD1MMP8KMT2A | |
| SCHEMBL7101012 | 0.77 | OPRK1 (1.00) | OPRK1OPRD1POLB | |
| SCHEMBL7106526 | 0.75 | OPRK1 (1.00) | OPRK1OPRD1KMT2A | |
| SCHEMBL7108642 | 0.74 | OPRK1 (1.00) | OPRK1OPRD1EPHX2KMT2A | |
| SCHEMBL7105487 | 0.73 | OPRK1 (0.64) | OPRK1OPRD1 | |
| SCHEMBL7106995 | 0.72 | OPRK1 (0.89) | OPRK1OPRD1POLBMMP8 | |
| SCHEMBL7106593 | 0.72 | OPRK1 (0.75) | OPRK1OPRD1POLBMMP8CYP2C9 | |
| SCHEMBL12356333 | 0.72 | POLB (1.00) | OPRK1POLBMMP8CNR1EPHX2 | |
| SCHEMBL7108645 | 0.70 | OPRK1 (1.00) | OPRK1OPRD1POLBMMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1055665-B1 | 3-(3-Hydroxyphenyl)-3-amino-propionamide derivatives | PFIZER PROD INC (US) | 2003-10-22 | — | — | EP | disclosed |
| EP-1055665-A1 | 3-(3-Hydroxyphenyl)-3-amino-propionamide derivatives | Pfizer Products Inc. (US) | 2000-11-29 | — | — | EP | disclosed |