Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 11/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.79 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7106355 | 0.88 | OPRK1 (1.00) | OPRK1OPRD1MMP1MMP2MMP9 | |
| SCHEMBL7101712 | 0.86 | OPRK1 (1.00) | OPRK1OPRD1MMP8KMT2A | |
| SCHEMBL7106526 | 0.85 | OPRK1 (1.00) | OPRK1OPRD1MEN1LMNAKMT2A | |
| SCHEMBL7106987 | 0.85 | OPRK1 (0.73) | OPRK1OPRD1 | |
| SCHEMBL7101012 | 0.81 | OPRK1 (1.00) | OPRK1OPRD1LMNA | |
| SCHEMBL7108642 | 0.78 | OPRK1 (1.00) | OPRK1OPRD1MEN1KMT2A | |
| SCHEMBL5544358 | 0.72 | OPRK1 (0.66) | OPRK1RIPK1MMP8SMN1; SMN2MEN1 | |
| SCHEMBL3505448 | 0.71 | OPRK1 (0.54) | OPRK1RIPK1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL7106098 | 0.69 | OPRK1 (0.53) | OPRK1OPRD1MMP1MMP2MMP9 | |
| SCHEMBL1516186 | 0.69 | RIPK1 (0.71) | OPRK1RIPK1MMP8SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1055665-B1 | 3-(3-Hydroxyphenyl)-3-amino-propionamide derivatives | PFIZER PROD INC (US) | 2003-10-22 | — | — | EP | disclosed |
| EP-1055665-A1 | 3-(3-Hydroxyphenyl)-3-amino-propionamide derivatives | Pfizer Products Inc. (US) | 2000-11-29 | — | — | EP | disclosed |