Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 11/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 5/20 | 1.00 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7108642 | 0.94 | OPRK1 (1.00) | OPRK1OPRD1ITGB3ITGA2B | |
| SCHEMBL7106587 | 0.86 | OPRK1 (0.76) | OPRK1OPRD1POLB | |
| SCHEMBL7107673 | 0.81 | OPRK1 (0.77) | OPRK1OPRD1POLB | |
| SCHEMBL7102313 | 0.81 | OPRK1 (1.00) | OPRK1OPRD1LMNA | |
| SCHEMBL7106355 | 0.79 | OPRK1 (1.00) | OPRK1OPRD1RAB9ALMNAPOLB | |
| SCHEMBL7101712 | 0.77 | OPRK1 (1.00) | OPRK1OPRD1POLB | |
| SCHEMBL7106526 | 0.76 | OPRK1 (1.00) | OPRK1OPRD1LMNA | |
| SCHEMBL2842744 | 0.65 | OPRD1 (0.48) | OPRK1OPRD1HIF1AADRB2ADRB1 | |
| SCHEMBL2501419 | 0.65 | OPRD1 (0.48) | OPRK1OPRD1HIF1AADRB2ADRB1 | |
| SCHEMBL2504416 | 0.65 | OPRD1 (0.48) | OPRK1OPRD1HIF1AADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1055665-B1 | 3-(3-Hydroxyphenyl)-3-amino-propionamide derivatives | PFIZER PROD INC (US) | 2003-10-22 | — | — | EP | disclosed |
| EP-1055665-A1 | 3-(3-Hydroxyphenyl)-3-amino-propionamide derivatives | Pfizer Products Inc. (US) | 2000-11-29 | — | — | EP | disclosed |