Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 2/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | LTK | P29376 | 1/20 | 0.43 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24893653 | 0.83 | CES1 (0.56) | MAOAALDH1A1KDM4EHPGDCES1 | |
| Fluorene SCHEMBL8180 | 0.82 | MAOA (0.68) | MAOAALDH1A1KDM4ENPC1MAPT | |
| Fluorene SCHEMBL545861 | 0.82 | MAOA (0.68) | MAOAALDH1A1KDM4ENPC1MAPT | |
| Fluorene SCHEMBL29478468 | 0.82 | MAOA (0.68) | MAOAALDH1A1KDM4ENPC1MAPT | |
| Fluorene SCHEMBL31388525 | 0.82 | MAOA (0.68) | MAOAALDH1A1KDM4ENPC1MAPT | |
| Fluorene SCHEMBL29355380 | 0.82 | MAOA (0.68) | MAOAALDH1A1KDM4ENPC1MAPT | |
| Fluorene SCHEMBL19610620 | 0.79 | MAOA (0.65) | MAOAALDH1A1KDM4ENPC1MAPT | |
| Fluorene SCHEMBL14118022 | 0.79 | MAOA (0.65) | MAOAALDH1A1KDM4ENPC1MAPT | |
| Fluorene SCHEMBL10626727 | 0.79 | MAOA (0.65) | MAOAALDH1A1KDM4ENPC1MAPT | |
| Fluorene SCHEMBL9435671 | 0.79 | MAOA (0.65) | MAOAALDH1A1KDM4ENPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170312363-A1 | MULTIFUNCTIONALIZED POLYETHYLENE GLYCOL DERIVATIVE AND PREPARATION METHOD THEREFOR | XIAMEN SINOPEG BIOTECH CO., LTD. (CN) | 2017-11-02 | — | — | US | disclosed |
| US-20170312363-A1 | MULTIFUNCTIONALIZED POLYETHYLENE GLYCOL DERIVATIVE AND PREPARATION METHOD THEREFOR | XIAMEN SINOPEG BIOTECH CO., LTD. (CN) | 2017-11-02 | — | — | US | disclosed |
| US-9381254-B2 | Methods for preparing polymeric reagents | NEKTAR THERAPEUTICS (US) | 2016-07-05 | — | — | US | disclosed |
| WO-2016050209-A1 | HETEROFUNCTIONALIZED POLYETHYLENE GLYCOL DERIVATIVE, PREPARATION METHOD, AND BIO-RELATED SUBSTANCE | 厦门赛诺邦格生物科技有限公司 | 2016-04-07 | — | — | WO | disclosed |
| WO-2016050210-A1 | MULTIFUNCTIONALIZED POLYETHYLENE GLYCOL DERIVATIVE AND PREPARATION METHOD THEREFOR | 厦门赛诺邦格生物科技有限公司 | 2016-04-07 | — | — | WO | disclosed |
| WO-2016050208-A1 | BIO-RELATED SUBSTANCE MODIFIED BY MULTIFUNCTIONALIZED POLYETHYLENE GLYCOL DERIVATIVE | 厦门赛诺邦格生物科技有限公司 | 2016-04-07 | — | — | WO | disclosed |
| US-20160022830-A1 | METHODS FOR PREPARING POLYMERIC REAGENTS | NEKTAR THERAPEUTICS | 2016-01-28 | — | — | US | disclosed |
| US-20150141665-A1 | METHODS FOR PREPARING POLYMERIC REAGENTS | NEKTAR THERAPEUTICS (US) | 2015-05-21 | — | — | US | disclosed |
| US-8905235-B2 | Polymeric reagents comprising a terminal vinylic group and conjugates formed therefrom | NEKTAR THERAPEUTICS (US) | 2014-12-09 | — | — | US | disclosed |
| EP-2319882-B1 | POLYOLEFIN RESIN COMPOSITION | ADEKA CORP (JP) | 2013-10-09 | — | — | EP | disclosed |
| US-4256889-A | MULTISTEP | MERCK & CO., INC. (US) | 1981-03-17 | — | — | US | disclosed |
| US-4252810-A | ANTIANXIETY AGENTS, MUSCLE RELAXANTS, ANTIPARKINSON DISEASE AGENT | MERCK & CO., INC. (US) | 1981-02-24 | — | — | US | disclosed |
| EP-0019866-A1 | Process for the preparation of 10,11-dihydro-5H-dibenzo (a,d)cyclohepten-5,10-imines | MERCK & CO. INC. (US) | 1980-12-10 | — | — | EP | disclosed |
| US-4232158-A | REACTION OF 5H-DIBENZ(A,D)CYCLOHEPTEN-5-ONE AND AMMONIA; ACYLATION, HYDROGENATION, AND CYCLIZATION | MERCK & CO., INC. (US) | 1980-11-04 | — | — | US | disclosed |
| US-4229455-A | MUSCLE RELAXANTS, TRANQUILIZERS | MERCK & CO., INC. (US) | 1980-10-21 | — | — | US | disclosed |
| EP-0011206-A1 | 9,10-Dihydro-4H-benzo(4,5)cyclohepta(1,2-b)thiophen-4,9 imines, process for their preparation and pharmaceutical compositions containing them | MERCK & CO. INC. (US) | 1980-05-28 | — | — | EP | disclosed |
| EP-0002512-A1 | Imino-bridged benzocycloheptapyridines, process for their preparation and pharmaceutical composition thereof | MERCK & CO. INC. (US) | 1979-06-27 | — | — | EP | disclosed |
| US-4064139-A | TRANQUILIZERS, ANTICONVULSANTS, MUSCLE RELAXANTS, ANTI-PARKINSON'S DISEASE | MERCK & CO., INC. (US) | 1977-12-20 | — | — | US | disclosed |
| US-4064139-A | TRANQUILIZERS, ANTICONVULSANTS, MUSCLE RELAXANTS, ANTI-PARKINSON'S DISEASE | MERCK & CO., INC. (US) | 1977-12-20 | — | — | US | disclosed |
| US-4064139-A | TRANQUILIZERS, ANTICONVULSANTS, MUSCLE RELAXANTS, ANTI-PARKINSON'S DISEASE | MERCK & CO., INC. (US) | 1977-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150141665-A1 | METHODS FOR PREPARING POLYMERIC REAGENTS | PAM, ALKBH3, DNPEP | MAOA 1085/4885ALDH1A1 2387/4885KDM4E 1014/4885 |
| US-20160022830-A1 | METHODS FOR PREPARING POLYMERIC REAGENTS | PAM, ALKBH3, DNPEP | MAOA 1085/4885ALDH1A1 2387/4885KDM4E 1014/4885 |
| US-20170312363-A1 | MULTIFUNCTIONALIZED POLYETHYLENE GLYCOL DERIVATIVE AND PREPARATION METHOD THEREFOR | HDGF, F11, F12 | MAOA 3271/4885ALDH1A1 1582/4885KDM4E 4115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.