Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.51 |
| ▸ | CASR | P41180 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19283574 | 1.00 | ALDH1A1 (0.58) | ALDH1A1GPR55MEN1KMT2AMAPT | |
| SCHEMBL15412316 | 1.00 | ALDH1A1 (0.58) | ALDH1A1GPR55MEN1KMT2AMAPT | |
| SCHEMBL1509273 | 0.81 | RAB9A (0.50) | ALDH1A1MEN1KMT2AMAPTRAB9A | |
| Cadaverine Tartrate SCHEMBL28944290 | 0.81 | CXCL8 (0.45) | ALDH1A1GPR55MEN1KMT2AMAPT | |
| SCHEMBL2712814 | 0.79 | KCNQ2 (0.59) | ALDH1A1GPR55MEN1KMT2AMAPT | |
| SCHEMBL3497579 | 0.79 | RAB9A (0.56) | ALDH1A1MAPTRAB9ANPC1POLB | |
| SCHEMBL3347123 | 0.79 | RAB9A (0.56) | ALDH1A1MAPTRAB9ANPC1POLB | |
| SCHEMBL3347133 | 0.79 | RAB9A (0.56) | ALDH1A1MAPTRAB9ANPC1POLB | |
| SCHEMBL3499028 | 0.79 | KMT2A (0.57) | ALDH1A1MEN1KMT2AMAPTRAB9A | |
| SCHEMBL6348906 | 0.79 | KCNQ2 (0.58) | ALDH1A1GPR55MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3527573-B9 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | GILEAD SCIENCES INC (US) | 2022-07-06 | — | — | EP | disclosed |
| US-10975096-B2 | Synthesis of polycyclic-carbamoylpyridone compounds | GILEAD SCIENCES, INC. (US) | 2021-04-13 | — | — | US | disclosed |
| EP-3783001-A1 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | Gilead Sciences, Inc. (US) | 2021-02-24 | — | — | EP | disclosed |
| EP-3527573-B1 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | GILEAD SCIENCES INC (US) | 2020-08-12 | — | — | EP | disclosed |
| US-20200223866-A1 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | GILEAD SCIENCES, INC. | 2020-07-16 | — | — | US | disclosed |
| EP-3527573-A1 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | Gilead Sciences, Inc. (US) | 2019-08-21 | — | — | EP | disclosed |
| US-20180022757-A1 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | GILEAD SCIENCES, INC. | 2018-01-25 | — | — | US | disclosed |
| EP-3157933-A2 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | Gilead Sciences, Inc. (US) | 2017-04-26 | — | — | EP | disclosed |
| US-20150368264-A1 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | GILEAD SCIENCES, INC. | 2015-12-24 | — | — | US | disclosed |
| WO-2015195656-A2 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | GILEAD SCIENCES ,INC. (US) | 2015-12-23 | — | — | WO | disclosed |
| EP-0969002-B1 | L-tartrate of trans-(-)-4-(4-fluorophenyl)-3-hydroxymethyl-piperidine compound and process for preparing the same | SUMIKA FINE CHEMICALS CO LTD (JP) | 2003-08-27 | — | — | EP | disclosed |
| US-20020028944-A1 | L-tartrate of trans-(-)-4-(4-fluorophenyl)-3-hydroxymethylpiperidine compound and process for preparing the same | SUMIKA FINE CHEMICALS CO., LTD. | 2002-03-07 | — | — | US | disclosed |
| US-6316628-B1 | REACTING A TRANS-(.+-.)-4-(4-FLUOROPHENYL)-3-HYDROXYMETHYLPIPERIDINE COMPOUND WITH L-TARTARIC ACID IN METHANOL, OR A MIXED SOLVENT OF METHANOL AND ISOPROPYL ALCOHOL OR ACETONE | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| EP-0969002-A1 | L-tartrate of trans-(-)-4-(4-fluorophenyl)-3-hydroxymethyl-piperidine compound and process for preparing the same | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 2000-01-05 | — | — | EP | disclosed |
| US-4105695-A | LEARNING ENHANCEMENT, IMPROVES MENTAL ALERTNESS OF GERIATRICS | BRISTOL-MYERS COMPANY (US) | 1978-08-08 | — | — | US | disclosed |
| US-4034113-A | Treatment of senile geriatric patients to restore performance | SHULGIN ALEXANDER T | 1977-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150368264-A1 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | CPS1, SDHA, DHPS | ALDH1A1 883/4885GPR55 4651/4885MEN1 290/4885 |
| US-20200223866-A1 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | CPS1, SDHA, DHPS | ALDH1A1 883/4885GPR55 4651/4885MEN1 290/4885 |
| US-20020028944-A1 | L-tartrate of trans-(-)-4-(4-fluorophenyl)-3-hydroxymethylpiperidine compound and process for preparing the same | TPH1, TPH2, TKT | ALDH1A1 372/4885GPR55 1515/4885MEN1 3725/4885 |
| US-20180022757-A1 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | CPS1, SDHA, DHPS | ALDH1A1 883/4885GPR55 4651/4885MEN1 290/4885 |
| US-10975096-B2 | Synthesis of polycyclic-carbamoylpyridone compounds | CPS1, SDHA, DHPS | ALDH1A1 883/4885GPR55 4651/4885MEN1 290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.