Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 7/20 | 0.54 |
| ▸ | CTSV | O60911 | 1/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | GABRP | O00591 | 5/20 | 0.47 |
| ▸ | GABRD | O14764 | 5/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.47 |
| ▸ | GABRB1 | P18505 | 5/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.47 |
| ▸ | GABRA4 | P48169 | 5/20 | 0.47 |
| ▸ | GABRE | P78334 | 5/20 | 0.47 |
| ▸ | GABRA6 | Q16445 | 5/20 | 0.47 |
| ▸ | GABRG1 | Q8N1C3 | 5/20 | 0.47 |
| ▸ | GABRG3 | Q99928 | 5/20 | 0.47 |
| ▸ | GABRQ | Q9UN88 | 5/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7109746 | 1.00 | KIF11 (0.54) | KIF11CTSVCTSLMAOAGABRP | |
| SCHEMBL8182735 | 0.80 | CTSV (0.48) | KIF11CTSVCTSLMAOAGABRA1 | |
| SCHEMBL14027323 | 0.80 | KIF11 (0.51) | KIF11CTSVCTSLMAOAGABRP | |
| SCHEMBL7810203 | 0.80 | CTSV (0.48) | KIF11CTSVCTSLMAOAGABRA1 | |
| SCHEMBL6009648 | 0.80 | KIF11 (0.61) | KIF11CTSVCTSLGABRPGABRD | |
| SCHEMBL7809148 | 0.78 | ADRB2 (0.64) | ALDH1A1MAPT | |
| SCHEMBL12722429 | 0.77 | GABRP (0.58) | KIF11CTSVCTSLMAOAGABRP | |
| SCHEMBL16790723 | 0.77 | GABRP (0.61) | KIF11CTSVCTSLGABRPGABRD | |
| SCHEMBL7108868 | 0.77 | KIF11 (0.54) | KIF11CTSVCTSLMAOAGABRP | |
| SCHEMBL7247905 | 0.76 | KIF11 (0.61) | KIF11CTSVCTSLGABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882707-B1 | NOVEL TRICYCLIC COMPOUNDS AND DRUG COMPOSITIONS CONTAINING THE SAME | ASAHI CHEMICAL IND (JP) | 2003-10-08 | — | — | EP | disclosed |
| US-20030139475-A1 | Novel tricyclic compounds and drug compositions containing same | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 2003-07-24 | — | — | US | disclosed |
| US-6545053-B1 | Aminoethoxyfluorene derivatives are beta-3 adrenaline receptor agonists and are useful as drugs for the treatment and prevention of diabetes, obesity, hyperlipemia, etc. | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 2003-04-08 | — | — | US | disclosed |
| US-6187809-B1 | BETA-3 ADRENALINE RECEPTOR AGONIST DRUGS FOR THE TREATMENT OF DIABETES, OBESITY, AND HYPERLIPEMIA; 2-(N-(2-(DIBENZOFURAN-3-YLOXY)ETHYL)AMINO)-1-PHENYLETHANOL, FOR EXAMPLE | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 2001-02-13 | — | — | US | disclosed |
| US-6037362-A | CARBAZOLE DERIVATIVES; DEPROTECTING, AMINATION; ANTILIPEMIC AND ANTIDIABETIC AGENTS; B-ADRENALINE RECEPTOR AGONISTS; DIETETICS | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 2000-03-14 | — | — | US | disclosed |
| EP-0882707-A1 | NOVEL TRICYCLIC COMPOUNDS AND DRUG COMPOSITIONS CONTAINING THE SAME | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1998-12-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030139475-A1 | Novel tricyclic compounds and drug compositions containing same | ADRB3, MC2R, NR3C1 | KIF11 4828/4885CTSV 4729/4885CTSL 4710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.