Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14147255 | 0.97 | — | — | |
| SCHEMBL290709 | 0.97 | — | — | |
| SCHEMBL15619029 | 0.80 | THRB (0.46) | — | |
| SCHEMBL18533728 | 0.79 | ALDH1A1 (0.39) | — | |
| SCHEMBL2278577 | 0.79 | — | — | |
| SCHEMBL8655511 | 0.79 | THRB (0.36) | — | |
| SCHEMBL17867300 | 0.79 | THRB (0.36) | — | |
| SCHEMBL3949692 | 0.79 | THRB (0.36) | — | |
| SCHEMBL283758 | 0.79 | THRB (0.36) | — | |
| SCHEMBL17866824 | 0.79 | THRB (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9265716-B2 | Hoya carnosa extracts and methods of use | AVON PRODUCTS, INC. (US) | 2016-02-23 | — | — | US | disclosed |
| US-9186316-B2 | Stephanotis jasminoides extracts and methods of use | AVON PRODUCTS, INC. (US) | 2015-11-17 | — | — | US | disclosed |
| US-9168283-B2 | Medemia nobilis extracts and methods of use | AVON PRODUCTS, INC. (US) | 2015-10-27 | — | — | US | disclosed |
| US-20150290119-A1 | Stephanotis Jasminoides Extracts and Methods of Use | AVON PRODUCTS, INC. (US) | 2015-10-15 | — | — | US | disclosed |
| US-20150290118-A1 | Hoya Carnosa Extracts and Methods of Use | AVON PRODUCTS, INC. (US) | 2015-10-15 | — | — | US | disclosed |
| US-20150164776-A1 | Callistephus Chinensis Extracts and Methods of Use | AVON PRODUCTS, INC. | 2015-06-18 | — | — | US | disclosed |
| US-8999403-B2 | Serissa japonica extracts and methods of use | AVON PRODUCTS, INC. (US) | 2015-04-07 | — | — | US | disclosed |
| US-8865231-B2 | Hoya carnosa extracts and methods of use | AVON PRODUCTS, INC. (US) | 2014-10-21 | — | — | US | disclosed |
| US-20140301962-A1 | Serissa Japonica Extracts and Methods of Use | AVON PRODUCTS, INC. | 2014-10-09 | — | — | US | disclosed |
| US-20140161911-A1 | Hoya Carnosa Extracts and Methods of Use | AVON PRODUCTS, INC. (US) | 2014-06-12 | — | — | US | disclosed |
| US-20140161909-A1 | Medemia Nobilis Extracts and Methods of Use | AVON PRODUCTS, INC. (US) | 2014-06-12 | — | — | US | disclosed |
| EP-1348421-A2 | A method of thickening and styling human keratinous fibres using a particular catalytic system | L'OREAL (FR) | 2003-10-01 | — | — | EP | disclosed |
| EP-0486499-B1 | STABLE ASCORBIC ACID COMPOSITIONS | UNIV DUKE (US) | 1997-08-06 | — | — | EP | disclosed |