Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.56 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.55 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.55 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.55 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.54 |
| ▸ | CBS | P35520 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1875367 | 0.86 | L3MBTL1 (0.73) | L3MBTL1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL20981664 | 0.85 | L3MBTL1 (0.82) | L3MBTL1NPC1RAB9APDK1PDK2 | |
| SCHEMBL7193391 | 0.85 | L3MBTL1 (0.61) | L3MBTL1NPC1RAB9AALDH1A1PDK1 | |
| SCHEMBL10277409 | 0.85 | L3MBTL1 (0.61) | L3MBTL1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL7824768 | 0.83 | NPSR1 (0.78) | L3MBTL1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL3200467 | 0.82 | MEN1 (0.53) | L3MBTL1MEN1KMT2APOLBCA12 | |
| SCHEMBL7194329 | 0.80 | RAB9A (0.56) | L3MBTL1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL23932088 | 0.80 | KMT2A (0.66) | L3MBTL1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL4749812 | 0.80 | NPC1 (0.80) | MEN1KMT2ANPC1RAB9APOLB | |
| SCHEMBL6622461 | 0.79 | HDAC1 (0.71) | L3MBTL1MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153645-B2 | Use of analgesics to treat chronic pain using sodium channel modulators | ALLERGAN, INC. (US) | 2012-04-10 | — | — | US | disclosed |
| US-8124612-B2 | Treating neurological disorders using selective antagonists of persistent sodium current | ALLERGAN, INC. (US) | 2012-02-28 | — | — | US | disclosed |
| US-7767718-B2 | Treating pain using selective antagonists of persistent sodium current | ALLERGAN, INC. (US) | 2010-08-03 | — | — | US | disclosed |
| US-7763651-B2 | Treating pain using selective antagonists of persistent sodium current | ALLERGAN, INC. (US) | 2010-07-27 | — | — | US | disclosed |
| US-7728034-B2 | Treating neurological disorders using selective antagonists of persistent sodium current | ALLERGAN, INC. (US) | 2010-06-01 | — | — | US | disclosed |
| US-7705055-B2 | Treating neurological disorders using selective antagonists of persistent sodium current | ALLERGAN, INC. (US) | 2010-04-27 | — | — | US | disclosed |
| US-20060287399-A1 | TREATING PAIN USING SELECTIVE ANTAGONISTS OF PERSISTENT SODIUM CURRENT | EHRING GEORGE R | 2006-12-21 | — | — | US | disclosed |
| US-20060287366-A1 | TREATING PAIN USING SELECTIVE ANTAGONISTS OF PERSISTENT SODIUM CURRENT | EHRING GEORGE R | 2006-12-21 | — | — | US | disclosed |
| US-20060264503-A1 | TREATING PAIN USING SELECTIVE ANTAGONISTS OF PERSISTENT SODIUM CURRENT | EHRING GEORGE R | 2006-11-23 | — | — | US | disclosed |
| US-7125908-B2 | Treating pain using selective antagonists of persistent sodium current | ALLERGAN, INC. (US) | 2006-10-24 | — | — | US | disclosed |
| US-7060723-B2 | Treating neurological disorders using selective antagonists of persistent sodium current | ALLERGAN, INC. (US) | 2006-06-13 | — | — | US | disclosed |
| EP-1658065-A2 | USING SELECTIVE ANTAGONISTS OF PERSISTENT SODIUM CURRENT TO TREAT NEUROLOGICAL DISORDERS AND PAIN | Allergan, Inc. (US) | 2006-05-24 | — | — | EP | disclosed |
| US-20060106112-A1 | Treating neurological disorders using selective antagonists of persistent sodium current | ALLERGAN, INC. (US) | 2006-05-18 | — | — | US | disclosed |
| US-20060106103-A1 | Treating neurological disorders using selective antagonists of persistent sodium current | ALLERGAN, INC. (US) | 2006-05-18 | — | — | US | disclosed |
| US-20050054695-A1 | Treating neurological disorders using selective antagonists of persistent sodium current | ALLERGAN, INC. | 2005-03-10 | — | — | US | disclosed |
| WO-2005020982-A2 | USING SELECTIVE ANTAGONISTS OF PERSISTENT SODIUM CURRENT TO TREAT NEUROLOGICAL DISORDERS AND PAIN | ALLERGAN, INC. (US) | 2005-03-10 | — | — | WO | disclosed |
| US-20050049287-A1 | Treating pain using selective antagonists of persistent sodium current | ALLERGAN, INC. | 2005-03-03 | — | — | US | disclosed |
| US-6590123-B2 | For cancer theapy | MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY | 2003-07-08 | — | — | US | disclosed |
| US-20020022747-A1 | Aminobenzoic acid derivatives having anti-tumorigenic activity, methods of making and using the same | BEKESI GEORGE J (US) | 2002-02-21 | — | — | US | disclosed |
| US-6294695-B1 | HALOACETOAMIDOBENZOYLUREAS OR ETHYL HALOACETOAMIDOBENZOATES | MOUNT SINAI SCHOOL OF MEDICINE OF THE CITY UNIVERSITY OF NEW YORK | 2001-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050049287-A1 | Treating pain using selective antagonists of persistent sodium current | KCNN3, KCNN2, SCN1B | L3MBTL1 1338/4885MEN1 3787/4885KMT2A 2161/4885 |
| US-20020022747-A1 | Aminobenzoic acid derivatives having anti-tumorigenic activity, methods of making and using the same | ABAT, DDC, GABBR2 | L3MBTL1 759/4885MEN1 2692/4885KMT2A 914/4885 |
| US-20050054695-A1 | Treating neurological disorders using selective antagonists of persistent sodium current | SCN1A, KCNN2, KCNN1 | L3MBTL1 636/4885MEN1 1200/4885KMT2A 2006/4885 |
| US-20060106112-A1 | Treating neurological disorders using selective antagonists of persistent sodium current | SCN1A, KCNN2, KCNN1 | L3MBTL1 636/4885MEN1 1200/4885KMT2A 2006/4885 |
| US-20060287366-A1 | TREATING PAIN USING SELECTIVE ANTAGONISTS OF PERSISTENT SODIUM CURRENT | KCNN3, KCNN2, SCN1B | L3MBTL1 1338/4885MEN1 3787/4885KMT2A 2161/4885 |
| US-20060264503-A1 | TREATING PAIN USING SELECTIVE ANTAGONISTS OF PERSISTENT SODIUM CURRENT | KCNN3, KCNN2, SCN1B | L3MBTL1 1338/4885MEN1 3787/4885KMT2A 2161/4885 |
| US-20060106103-A1 | Treating neurological disorders using selective antagonists of persistent sodium current | SCN1A, KCNN2, KCNN1 | L3MBTL1 636/4885MEN1 1200/4885KMT2A 2006/4885 |
| US-20060287399-A1 | TREATING PAIN USING SELECTIVE ANTAGONISTS OF PERSISTENT SODIUM CURRENT | KCNN3, KCNN2, SCN1B | L3MBTL1 1338/4885MEN1 3787/4885KMT2A 2161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.