Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.44 |
| ▸ | MMP13 | P45452 | 5/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.40 |
| ▸ | FNTA | P49354 | 2/20 | 0.39 |
| ▸ | FNTB | P49356 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7078041 | 0.91 | RORC (0.47) | RORCDHODHMMP2MMP8ALDH1A1 | |
| SCHEMBL7078046 | 0.89 | DHODH (0.42) | RORCMMP13DHODHMMP2MMP8 | |
| SCHEMBL7078136 | 0.88 | MMP2 (0.58) | DHODHMMP2MMP8FNTAFNTB | |
| SCHEMBL8360105 | 0.87 | RORC (0.43) | RORCDHODHMMP2MMP8ALDH1A1 | |
| SCHEMBL7078388 | 0.82 | NAMPT (0.44) | LMNANAMPTCYP2C9 | |
| SCHEMBL7080988 | 0.81 | ITGB3 (0.44) | RORCALDH1A1LMNANPC1MAPT | |
| SCHEMBL7077549 | 0.80 | DHODH (0.44) | RORCDHODHMMP2MMP8ALDH1A1 | |
| SCHEMBL7078927 | 0.76 | CA12 (0.44) | MMP13MMP2ALDH1A1LMNAMAPT | |
| SCHEMBL7132373 | 0.75 | SCN1A (0.46) | MMP13ALDH1A1LMNAMAPTRAB9A | |
| SCHEMBL11772950 | 0.75 | DHODH (0.50) | DHODHMMP2MMP8ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003059872-A1 | AVB3 AND AVB5 INTEGRIN ANTAGONISTS AND METHODS OF TREATING DISEASES OR CONDITIONS ASSOCIATED WITH AVB3 AND AVB5 INTEGRINS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-07-24 | — | — | WO | disclosed |