Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 14/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 8/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7078388 | 0.91 | NAMPT (0.44) | NAMPTCYP2C9LMNA | |
| SCHEMBL7130423 | 0.91 | RORC (0.44) | RORCDHODHMMP2MMP8NAMPT | |
| SCHEMBL7078136 | 0.91 | MMP2 (0.58) | DHODHMMP2MMP8 | |
| SCHEMBL8360105 | 0.90 | RORC (0.43) | RORCDHODHMMP2MMP8NAMPT | |
| SCHEMBL7077549 | 0.89 | DHODH (0.44) | RORCDHODHMMP2MMP8NAMPT | |
| SCHEMBL7080988 | 0.83 | ITGB3 (0.44) | RORCCYP2C9ALDH1A1LMNAATM | |
| SCHEMBL7078046 | 0.80 | DHODH (0.42) | RORCDHODHMMP2MMP8NAMPT | |
| SCHEMBL7135413 | 0.79 | GRM4 (0.53) | LMNA | |
| SCHEMBL7080823 | 0.78 | GABBR2 (0.49) | MMP2CYP2C9ALDH1A1LMNA | |
| SCHEMBL8909238 | 0.77 | GABBR2 (0.56) | MMP2ALDH1A1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003059872-A1 | AVB3 AND AVB5 INTEGRIN ANTAGONISTS AND METHODS OF TREATING DISEASES OR CONDITIONS ASSOCIATED WITH AVB3 AND AVB5 INTEGRINS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-07-24 | — | — | WO | disclosed |