Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.52 |
| ▸ | MMP8 | P22894 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27395590 | 1.00 | LTA4H (0.52) | LTA4HMMP8KMT2AMAPTGAA | |
| SCHEMBL7524502 | 0.88 | ALDH1A1 (0.55) | MMP8KMT2AMAPTEGFRSRC | |
| SCHEMBL8549363 | 0.88 | ALDH1A1 (0.55) | MMP8KMT2AMAPTEGFRSRC | |
| SCHEMBL26303620 | 0.88 | ALDH1A1 (0.55) | MMP8KMT2AMAPTEGFRSRC | |
| SCHEMBL18274706 | 0.85 | SLC1A1 (0.61) | MMP8KMT2AMAPTEGFRSRC | |
| SCHEMBL1697377 | 0.84 | MMP8 (0.53) | MMP8KMT2AGAAEGFRSRC | |
| SCHEMBL5653978 | 0.84 | MMP8 (0.53) | MMP8KMT2AGAAEGFRSRC | |
| SCHEMBL3114367 | 0.84 | ALPI (0.61) | LTA4HMMP8KMT2AEGFRSRC | |
| SCHEMBL7413310 | 0.84 | ALPI (0.61) | LTA4HMMP8KMT2AEGFRSRC | |
| SCHEMBL47278 | 0.84 | MMP8 (0.53) | MMP8KMT2AGAAEGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0928790-B1 | Thiazole derivatives | HOFFMANN LA ROCHE (CH) | 2003-03-05 | — | — | EP | disclosed |
| US-6437145-B1 | REACTING N-PROTECTED AMINODICARBOXYLIC ACIDS WITH A DEHYDRATING AGENT TO FORM CYCLIC ANHYDRIDES WHICH ARE REACTED WITH CARBONYL COMPOUNDS; FOR THE ALPHA-SELECTIVE PRODUCTION OF ESTERS OR AMIDES OF DICARBOXYLIC AMINO ACIDS | DEGUSSA-HULS AG (DE) | 2002-08-20 | — | — | US | disclosed |
| CN-1080720-C | Thiazole derivatives | HOFFMANN LA ROCHE (CH) | 2002-03-13 | — | — | CN | disclosed |
| US-6344562-B1 | ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. | 2002-02-05 | — | — | US | disclosed |
| US-20020010316-A1 | Thiazole derivatives | ALIG LEO (CH) | 2002-01-24 | — | — | US | disclosed |
| US-6320054-B1 | INHIBIT BINDING OF ADHESIVE PROTEINS TO THE SURFACE OF DIFFERENT TYPES F CELL AND ACCORDINGLY INFLUENCE CELL-CELL AND CELL-MATRIX INTERACTIONS. | HOFFMAN-LA ROCHE INC. | 2001-11-20 | — | — | US | disclosed |
| US-6100282-A | Thiazole derivatives | HOFFMAN-LA ROCHE INC. (US) | 2000-08-08 | — | — | US | disclosed |
| US-6051715-A | Method of producing oxazolidinones, the use thereof and novel oxazolidinones | DEGUSSA-HULS AG (DE) | 2000-04-18 | — | — | US | disclosed |
| CN-1224718-A | Thiazole derivatives | HOFFMANN LA ROCHE (CH) | 1999-08-04 | — | — | CN | disclosed |
| EP-0928790-A1 | Thiazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1999-07-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020010316-A1 | Thiazole derivatives | VCAM1, SOST, TGFB1 | LTA4H 2748/4885MMP8 1037/4885KMT2A 4510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.