SCHEMBL7146697

SCHEMBL7146697

Clc1ccc(-c2nncs2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FBP1 P09467 1/20 0.47
GAA P10253 3/20 0.47
KDM4E B2RXH2 3/20 0.47
MGAM O43451 2/20 0.47
SI P14410 2/20 0.47
MGAM2 Q2M2H8 2/20 0.47
NOTUM Q6P988 2/20 0.47
GFER P55789 1/20 0.43
RAB9A P51151 3/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
LMNA P02545 1/20 0.42
ADORA3 P0DMS8 1/20 0.41
ADORA2A P29274 1/20 0.41
ADORA2B P29275 1/20 0.41
ADORA1 P30542 1/20 0.41
KMT2A Q03164 3/20 0.37
ALDH1A1 P00352 2/20 0.37
CYP19A1 P11511 2/20 0.37
MEN1 O00255 2/20 0.37
NPC1 O15118 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3721048 0.78 ALDH1A1 (0.47) GAAKDM4ENOTUMRAB9ASMN1; SMN2
SCHEMBL7566383 0.78 KDM4E (0.42) FBP1KDM4ENOTUMRAB9ASMN1; SMN2
SCHEMBL9435348 0.78 GAA (0.47) GAAKDM4EMGAMSIMGAM2
SCHEMBL15739862 0.78 RAB9A (0.42) FBP1KDM4ERAB9ASMN1; SMN2LMNA
SCHEMBL11238301 0.78 PDPK1 (0.42) KDM4ERAB9ASMN1; SMN2LMNAKMT2A
SCHEMBL12925903 0.78 RAB9A (0.51) KDM4ENOTUMRAB9ASMN1; SMN2LMNA
SCHEMBL572719 0.77 PDPK1 (0.45) KDM4ERAB9ASMN1; SMN2ADORA3ADORA2A
SCHEMBL19219056 0.77 LMNA (0.46) KDM4ENOTUMRAB9ASMN1; SMN2LMNA
SCHEMBL31264268 0.76 NOTUM (0.46) NOTUMRAB9ASMN1; SMN2KMT2ACYP19A1
SCHEMBL3225350 0.76 KDM4E (0.45) KDM4ENOTUMRAB9ASMN1; SMN2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105248438-B Wheat is combined spray and preparation method thereof, application method and application 北京阿格瑞斯生物技术有限公司 2017-09-29 CN claimed
CN-105248438-A Composite spraying agent for wheat and preparation method, using method and application thereof BEIJING AGRICULTURE BIOTECHNOLOGY CO LTD 2016-01-20 CN claimed
US-20250325534-A1 MICROBIOCIDAL TETRAHYDROISOQUINOLINE DERIVATIVES SYNGENTA CROP PROTECTION AG (CH) 2025-10-23 US disclosed
US-20240343717-A1 MICROBIOCIDAL PYRAZOLE DERIVATIVES SYNGENTA CROP PROTECTION AG (CH) 2024-10-17 US disclosed
CN-111995620-B Preparation method of 1,3, 4-thiadiazole compound and compound prepared by same 重庆医科大学 2023-06-06 CN disclosed
CN-111995620-A Preparation method of 1,3, 4-thiadiazole compound and compound prepared by same 重庆医科大学 2020-11-27 CN disclosed
CN-105248438-A Composite spraying agent for wheat and preparation method, using method and application thereof BEIJING AGRICULTURE BIOTECHNOLOGY CO LTD 2016-01-20 CN disclosed
CN-105248438-A Composite spraying agent for wheat and preparation method, using method and application thereof BEIJING AGRICULTURE BIOTECHNOLOGY CO LTD 2016-01-20 CN disclosed
CN-104364239-A New diazaspirocycloalkane and azaspirocycloalkane HOFFMANN LA ROCHE 2015-02-18 CN disclosed
EP-1326853-A1 NEW THIADIAZOLES AND OXADIAZOLES AND THEIR USE AS PHOSPHODIESTERASE-7 INHIBITORS Warner-Lambert Company LLC (US) 2003-07-16 EP disclosed
WO-2002028847-A1 NEW THIADIAZOLES AND OXADIAZOLES AND THEIR USE AS PHOSPHODIESTERASE-7 INHIBITORS WARNER-LAMBERT COMPANY LLC (US) 2002-04-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250325534-A1 MICROBIOCIDAL TETRAHYDROISOQUINOLINE DERIVATIVES IFNG, NOX1, CYP1A1 FBP1 2514/4885GAA 1396/4885KDM4E 3002/4885
US-20240343717-A1 MICROBIOCIDAL PYRAZOLE DERIVATIVES NOX1, CASP1, CYP51A1 FBP1 744/4885GAA 1659/4885KDM4E 3689/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.