Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.48 |
| ▸ | HTR6 | P50406 | 5/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7146842 | 0.94 | BRD4 (0.47) | BRD4HTR6ADRA2AADRA2BADRA2C | |
| SCHEMBL8553359 | 0.78 | HIF1A (0.42) | HTR6MAPTGAAHTTSMN1; SMN2 | |
| SCHEMBL8549554 | 0.78 | HTR6 (0.42) | BRD4HTR6HTR7HTR2BMAPT | |
| SCHEMBL8180841 | 0.71 | HTR1F (0.44) | HTR6MAPTGAASMN1; SMN2 | |
| SCHEMBL7138773 | 0.70 | IMPDH2 (0.45) | BRD4HTR6MAPT | |
| SCHEMBL7145980 | 0.69 | HTR1F (0.43) | MAPTGAASMN1; SMN2 | |
| SCHEMBL7145054 | 0.68 | KMT2A (0.41) | MAPTGAAHTTSMN1; SMN2 | |
| SCHEMBL7141353 | 0.67 | HTR1F (0.36) | HTR6ADRA2AADRA2BADRA2CHTR7 | |
| SCHEMBL8197371 | 0.65 | NPC1 (0.49) | SMN1; SMN2 | |
| SCHEMBL7140329 | 0.63 | HTR1F (0.62) | HTR6ADRA2AADRA2BADRA2CHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997013512-A1 | N-[2-SUBSTITUTED-3-(2-AMINOETHYL)-1H-INDOL-5-YL]-AMIDES: NEW 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1997-04-17 | — | — | WO | disclosed |