Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGER | Q15109 | 2/20 | 0.69 |
| ▸ | ALOX5 | P09917 | 8/20 | 0.59 |
| ▸ | VCP | P55072 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.48 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CFTR | P13569 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16603960 | 0.83 | AGER (1.00) | AGERALOX5VCPCYP1A2CYP1A1 | |
| SCHEMBL7115473 | 0.83 | ALOX5 (0.73) | AGERALOX5VCPCYP1A2MAPT | |
| SCHEMBL7113308 | 0.80 | CYP1B1 (0.67) | AGERALOX5VCPCYP1A2CYP1A1 | |
| SCHEMBL7246864 | 0.80 | ALOX5 (0.79) | ALOX5VCPCYP1A2CYP1A1CYP1B1 | |
| SCHEMBL28908960 | 0.78 | AGER (0.62) | AGERALOX5VCPMAPTMEN1 | |
| SCHEMBL7114964 | 0.76 | ALOX5 (1.00) | ALOX5VCPCYP1A2MAPTMAPK1 | |
| SCHEMBL7115739 | 0.75 | ALOX5 (0.81) | ALOX5VCPCYP1A2CYP1A1CYP1B1 | |
| SCHEMBL7263150 | 0.74 | VCP (0.80) | ALOX5VCPCYP1A2CYP1A1CYP1B1 | |
| SCHEMBL23553570 | 0.73 | VCP (1.00) | ALOX5VCPMAPTKDM4EMAPK1 | |
| SCHEMBL7153995 | 0.73 | ALOX5 (0.62) | ALOX5VCPCYP1A2CYP1A1CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030220380-A1 | Substituted thiazoles and the use thereof as inhibitors of plasminogen activator inhibitor-1 | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2003-11-27 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030220380-A1 | Substituted thiazoles and the use thereof as inhibitors of plasminogen activator inhibitor-1 | SERPINE1, SERPINC1, SERPINB1 | AGER 439/4885ALOX5 2040/4885VCP 2778/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.