Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7618752 | 0.78 | ALDH1A1 (0.37) | HTR7HTR1AALDH1A1CYP2A6HSD17B10 | |
| SCHEMBL8574024 | 0.72 | CHRNB2 (0.35) | PDCD1CD274CHRNB2CHRNA4 | |
| SCHEMBL5694274 | 0.71 | PDCD1 (0.37) | PDCD1CD274CHRNB2CHRNA4HTR7 | |
| SCHEMBL27475455 | 0.67 | BRD4 (0.36) | PDCD1CD274HTR7ALDH1A1CYP2A6 | |
| SCHEMBL5090888 | 0.66 | LMNA (0.33) | DRD2ALDH1A1LMNATDP1TSHR | |
| SCHEMBL25785668 | 0.64 | PDCD1 (0.64) | PDCD1CD274HTR7ALDH1A1CYP2A6 | |
| SCHEMBL4603520 | 0.63 | PDCD1 (0.36) | PDCD1CD274CHRNB2CHRNA4HTR7 | |
| SCHEMBL60836 | 0.63 | PDCD1 (0.39) | PDCD1CD274ALDH1A1CYP2A6HSD17B10 | |
| SCHEMBL3294988 | 0.62 | LMNA (0.53) | PDCD1CD274ALDH1A1CYP2A6HSD17B10 | |
| SCHEMBL29688196 | 0.62 | LMNA (0.53) | PDCD1CD274ALDH1A1CYP2A6HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6538082-B2 | With an indenyl and partially or fully hydrogenated fluorenyl group | SOLVAY POLYOLEFINS EUROPE-BELGIUM (BE) | 2003-03-25 | — | — | US | disclosed |
| US-20020103312-A1 | Asymmetric silicon-bridged metallocenes useful as catalysts in the polymerization of alpha-olefins, process for their preparation and use of said metallocenes for the polymerization of alpha-olefins | INNOVENE MANUFACTURING BELGIUM NV (BE) | 2002-08-01 | — | — | US | disclosed |
| EP-1213295-A2 | Asymmetric silicon-bridged metallocenes useful as catalysts in the polymerization of Alpha-olefins, process for their preparation and use of said metallocenes for the polymerization of Alpha-olefins | Solvay Polyolefins Europe-Belgium (Société Anonyme) (BE) | 2002-06-12 | — | — | EP | disclosed |
| EP-0834519-B1 | CATALYST FOR POLYOLEFIN PRODUCTION AND PROCESS FOR PRODUCING POLYOLEFIN | JAPAN POLYOLEFINS CO LTD (JP) | 2002-03-06 | — | — | EP | disclosed |
| US-6121182-A | A METALLOCENE CATALYST FOR POLYMERIZATION OF ISOTACTIC POLYOLEFINS WITH HIGH RIGIDITY AND HIGH MELTING POINT, USEFUL AS INDUSTRIAL MATERIAL FOR AUTOMOBILES | JAPAN POLYOLAFINS CO., LTD. (JP) | 2000-09-19 | — | — | US | disclosed |
| EP-0834519-A1 | CATALYST FOR POLYOLEFIN PRODUCTION AND PROCESS FOR PRODUCING POLYOLEFIN | Japan Polyolefins Co., Ltd. (JP) | 1998-04-08 | — | — | EP | disclosed |