Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.60 |
| ▸ | PTGDR | Q13258 | 14/20 | 0.55 |
| ▸ | PTGDR2 | Q9Y5Y4 | 14/20 | 0.55 |
| ▸ | CCR2 | P41597 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8481368 | 0.90 | PTGS1 (0.52) | FFAR1PTGDRPTGDR2CCR2PTGS1 | |
| SCHEMBL7161648 | 0.87 | PTGS1 (0.52) | FFAR1PTGDRPTGDR2CCR2PTGS1 | |
| SCHEMBL8523577 | 0.85 | PTGS1 (0.58) | FFAR1PTGDRPTGDR2CCR2PTGS1 | |
| SCHEMBL8092078 | 0.80 | PTGS1 (0.48) | FFAR1PTGDRPTGDR2CCR2PTGS1 | |
| SCHEMBL8104954 | 0.77 | FFAR1 (0.70) | FFAR1 | |
| SCHEMBL8099545 | 0.76 | CCR2 (0.56) | FFAR1PTGDRPTGDR2CCR2PTGS1 | |
| SCHEMBL8481656 | 0.76 | PTGS1 (0.51) | FFAR1PTGDRPTGDR2CCR2PTGS1 | |
| SCHEMBL8099718 | 0.76 | PTGS1 (0.68) | CCR2PTGS1PTGS2 | |
| SCHEMBL12667945 | 0.76 | FFAR1 (1.00) | FFAR1 | |
| SCHEMBL7162523 | 0.74 | PTGS1 (0.59) | PTGDRPTGDR2CCR2PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE38103-E1 | 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2 | MERCK FROSST CANADA & CO. (CA) | 2003-04-29 | — | — | US | disclosed |
| EP-0848703-B1 | DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLO-OXYGENASE II | NYCOMED AUSTRIA GMBH (AT) | 2000-09-27 | — | — | EP | disclosed |
| EP-0673366-B1 | 5-METHANESULFONAMIDO-1-INDANONES AS AN INHIBITOR OF CYCLOOXYGENASE-2 | MERCK FROSST CANADA INC (CA) | 1998-10-14 | — | — | EP | disclosed |
| US-5604260-A | 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2 | MERCK FROSST CANADA INC. (CA) | 1997-02-18 | — | — | US | disclosed |
| EP-0673366-A1 | 5-METHANESULFONAMIDO-1-INDANONES AS AN INHIBITOR OF CYCLOOXYGENASE-2 | MERCK FROSST CANADA INC. (CA) | 1995-09-27 | — | — | EP | disclosed |
| WO-1994013635-A1 | 5-METHANESULFONAMIDO-1-INDANONES AS AN INHIBITOR OF CYCLOOXYGENASE-2 | MERCK FROSST CANADA INC. (CA) | 1994-06-23 | — | — | WO | disclosed |