Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | DRD1 | P21728 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8675744 | 0.76 | OPRM1 (0.40) | MAPTNPSR1LMNAKDM4ECHRM2 | |
| SCHEMBL7164266 | 0.67 | FAAH (0.49) | MAPTALDH1A1L3MBTL1 | |
| SCHEMBL7164530 | 0.66 | MGLL (0.48) | MAPTNPSR1LMNAKMT2AMEN1 | |
| SCHEMBL6929886 | 0.64 | ALDH1A1 (0.43) | MAPTNPSR1LMNAKDM4ECHRM2 | |
| SCHEMBL9819292 | 0.64 | CHRM2 (0.43) | CHRM2ADRA2ACHRM1DRD1DRD3 | |
| SCHEMBL16118505 | 0.61 | ALDH1A1 (0.46) | MAPTCYP2D6KMT2AALDH1A1HPGD | |
| SCHEMBL5164869 | 0.61 | ALDH1A1 (0.46) | MAPTCYP2D6KMT2AALDH1A1HPGD | |
| SCHEMBL2175411 | 0.61 | MGLL (0.44) | MAPTNPSR1LMNAKDM4ECHRM2 | |
| SCHEMBL17360649 | 0.59 | KMT2A (0.41) | MAPTNPSR1LMNAKDM4ECHRM2 | |
| SCHEMBL11650115 | 0.59 | MEN1 (0.42) | MAPTNPSR1LMNAKDM4ECYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562814-B2 | 3-thioxo-[1,2,4]-oxadiazinan-5-one derivatives | WYETH | 2003-05-13 | — | — | US | claimed |
| US-20020061883-A1 | 3-thioxo-[1,2,4]-oxadiazinan-5-one derivatives | AMERICAN HOME PRODUCTS CORPORATION | 2002-05-23 | — | — | US | claimed |
| WO-2002028845-A1 | 3-THIOXO-[1,2,4]-OXADIAZINAN-5-ONE AND THEIR USE AS ANTI-ANTHEROSCLEROTIC AGENTS | WYETH (US) | 2002-04-11 | — | — | WO | claimed |
| US-6562814-B2 | 3-thioxo-[1,2,4]-oxadiazinan-5-one derivatives | WYETH | 2003-05-13 | — | — | US | disclosed |
| US-20020061883-A1 | 3-thioxo-[1,2,4]-oxadiazinan-5-one derivatives | AMERICAN HOME PRODUCTS CORPORATION | 2002-05-23 | — | — | US | disclosed |
| WO-2002028845-A1 | 3-THIOXO-[1,2,4]-OXADIAZINAN-5-ONE AND THEIR USE AS ANTI-ANTHEROSCLEROTIC AGENTS | WYETH (US) | 2002-04-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020061883-A1 | 3-thioxo-[1,2,4]-oxadiazinan-5-one derivatives | AHR, PAOX, PPARA | MAPT 4600/4885NPSR1 1207/4885LMNA 3613/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.