Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | NAAA | Q02083 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10001149 | 0.91 | SMN1; SMN2 (0.62) | HPGDMEN1LMNAKMT2AL3MBTL1 | |
| SCHEMBL8496423 | 0.90 | ALDH1A1 (0.63) | ALDH1A1HPGDMEN1LMNAKMT2A | |
| SCHEMBL12031270 | 0.87 | SMN1; SMN2 (0.60) | HPGDNAAAMEN1LMNAKMT2A | |
| SCHEMBL7542456 | 0.86 | NAAA (0.63) | HPGDNAAALMNAL3MBTL1MAPT | |
| SCHEMBL16596169 | 0.81 | NAAA (0.69) | ALDH1A1HPGDNAAAMEN1KMT2A | |
| SCHEMBL4761104 | 0.80 | THRA (0.57) | HPGDNAAAMEN1LMNAKMT2A | |
| SCHEMBL24648927 | 0.79 | LMNA (0.62) | ALDH1A1HPGDLMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL1093862 | 0.79 | HPGD (0.91) | HPGDMEN1LMNAKMT2AL3MBTL1 | |
| SCHEMBL7327582 | 0.79 | ALDH1A1 (0.55) | ALDH1A1MEN1KMT2ASMN1; SMN2HTT | |
| Valerophenone SCHEMBL9725402 | 0.79 | L3MBTL1 (0.72) | HPGDLMNAKMT2AL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6566375-B1 | For therapy of atherosclerosis | WYETH | 2003-05-20 | — | — | US | disclosed |
| US-6316467-B1 | Elevation of HDL cholesterol by 4-[(Aminothioxomethyl)-hydrazono]-N-(substituted)-4-arylbutanamides | AMERICAN HOME PRODUCTS CORPORATION | 2001-11-13 | — | — | US | disclosed |
| WO-1999025682-A1 | ELEVATION OF HDL CHOLESTEROL BY 4-[(AMINOTHIOXOMETHYL) -HYDRAZONO] -N-(SUBSTITUTED) -4-ARYLBUTANAMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-05-27 | — | — | WO | disclosed |