Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.37 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7666697 | 0.77 | SMN1; SMN2 (0.43) | SMN1; SMN2KEAP1ALDH1A1MAPTFFAR2 | |
| SCHEMBL7674864 | 0.76 | LMNA (0.43) | SMN1; SMN2ALDH1A1MAPTKMT2ACYP1A2 | |
| SCHEMBL7169064 | 0.73 | TDP1 (0.40) | SMN1; SMN2ALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL1653895 | 0.72 | SMN1; SMN2 (0.64) | SMN1; SMN2KEAP1ALDH1A1MAPTSERPINE1 | |
| SCHEMBL7666695 | 0.71 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1MAPTFFAR2SERPINE1 | |
| SCHEMBL7981185 | 0.70 | SMN1; SMN2 (0.68) | SMN1; SMN2KEAP1ALDH1A1MAPTSERPINE1 | |
| SCHEMBL7978483 | 0.70 | SMN1; SMN2 (0.68) | SMN1; SMN2KEAP1ALDH1A1MAPTSERPINE1 | |
| SCHEMBL29157409 | 0.69 | SMN1; SMN2 (0.50) | SMN1; SMN2KEAP1ALDH1A1MAPTSERPINE1 | |
| SCHEMBL7170492 | 0.68 | ALDH1A1 (0.46) | SMN1; SMN2ALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL27433750 | 0.67 | ALPL (0.48) | SMN1; SMN2KEAP1ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657166-B1 | Combination containing a quinoxaline and a nucleoside | AVENTIS PHARMA GMBH (DE) | 2003-04-09 | — | — | EP | disclosed |
| US-6369057-B1 | VIRICIDES, IN PARTICULAR AGAINST RETROVIRUSES, HUMAN IMMUNODEFICIENCY VIRUS (HIV) | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-04-09 | — | — | US | disclosed |
| EP-0509398-B1 | Quinoxalines, process for their preparation and their use | AVENTIS PHARMA GMBH (DE) | 2001-09-19 | — | — | EP | disclosed |
| EP-0657166-A1 | Combination containing a quinoxaline and a nucleoside | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-06-14 | — | — | EP | disclosed |
| EP-0509398-A1 | Quinoxalines, process for their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-10-21 | — | — | EP | disclosed |