Sugi Predict

Sugi Predict / Compounds / SCHEMBL717757

SCHEMBL717757

SCHEMBL717757

O=C(O)NC(OCc1ccccc1)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SLC1A3 P43003 2/20 0.46
▸ SLC1A2 P43004 2/20 0.46
▸ SLC1A1 P43005 2/20 0.46
▸ CYP1A2 P05177 2/20 0.46
▸ MEN1 O00255 1/20 0.46
▸ CYP2D6 P10635 1/20 0.46
▸ CYP2C9 P11712 1/20 0.46
▸ CYP2C19 P33261 1/20 0.46
▸ KMT2A Q03164 1/20 0.46
▸ MMP9 P14780 2/20 0.45
▸ MMP8 P22894 2/20 0.45
▸ CNR2 P34972 1/20 0.45
▸ HTT P42858 1/20 0.44
▸ SMN1; SMN2 Q16637 1/20 0.44
▸ ALDH1A1 P00352 4/20 0.42
▸ CTSL P07711 1/20 0.42
▸ CTSS P25774 1/20 0.42
▸ CNR1 P21554 1/20 0.41
▸ NPC1 O15118 1/20 0.41
▸ RAB9A P51151 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5320044 0.87 SLC1A3 (0.47) SLC1A3SLC1A2SLC1A1CYP1A2MEN1
Iodide SCHEMBL7715452 0.81 MEN1 (0.47) CYP1A2MEN1CYP2D6CYP2C9CYP2C19
SCHEMBL4769827 0.77 MMP9 (0.48) SLC1A3SLC1A2SLC1A1CYP1A2MEN1
SCHEMBL3400152 0.76 CTRB1 (0.48) SLC1A3SLC1A2SLC1A1CYP1A2MEN1
SCHEMBL14675504 0.74 KMT2A (0.52) KMT2AMMP8ALDH1A1L3MBTL1
SCHEMBL27779846 0.74 SIGMAR1 (0.43) SLC1A3SLC1A2SLC1A1CYP1A2MEN1
SCHEMBL28502441 0.73 MMP9 (0.49) SLC1A1MMP9HTTSMN1; SMN2ALDH1A1
SCHEMBL20551984 0.73 PSMB5 (0.47) SLC1A3SLC1A2SLC1A1CYP1A2MEN1
SCHEMBL19305346 0.73 MMP9 (0.49) SLC1A1MMP9HTTSMN1; SMN2ALDH1A1
SCHEMBL15716272 0.73 PSMB5 (0.47) SLC1A3SLC1A2SLC1A1CYP1A2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113677334-B Transient receptor potential MELASTATIN 8 (TRPM 8) antagonists and related methods 马歇尔大学科研协会 2024-04-09 — — CN disclosed
US-20220313629-A1 TRANSIENT POTENTIAL MELASTATIN 8 (TRPM8) ANTAGONISTS AND RELATED METHODS MARSHALL UNIVERSITY RESEARCH CORPORATION 2022-10-06 — — US disclosed
EP-3917510-A1 TRANSIENT RECEPTOR POTENTIAL MELASTATIN 8 (TRPM8) ANTAGONISTS AND RELATED METHODS Marshall University Research Corporation (US) 2021-12-08 — — EP disclosed
WO-2020160464-A1 TRANSIENT RECEPTOR POTENTIAL MELASTATIN 8 (TRPM8) ANTAGONISTS AND RELATED METHODS MARSHALL UNIVERSITY RESEARCH CORPORATION (US) 2020-08-06 — — WO disclosed
US-9090639-B2 Cold menthol receptor-1 antagonists JANSSEN PHARMACEUTICA N.V. (BE) 2015-07-28 — — US disclosed
US-20140100194-A1 COLD MENTHOL RECEPTOR-1 ANTAGONISTS JANSSEN PHARMACEUTICA, NV (BE) 2014-04-10 — — US disclosed
US-8629281-B2 Cold menthol receptor-1 antagonists JANSSEN PHARMACEUTICA, NV (BE) 2014-01-14 — — US disclosed
US-8558011-B2 Cold menthol receptor-1 antagonists JANSSEN PHARMACEUTICA, NV (BE) 2013-10-15 — — US disclosed
EP-2029614-B1 COLD MENTHOL RECEPTOR-1 ANTAGONISTS JANSSEN PHARMACEUTICA NV (BE) 2013-01-23 — — EP disclosed
US-20120184510-A1 COLD MENTHOL RECEPTOR-1 ANTAGONISTS COLBURN RAYMOND W (US) 2012-07-19 — — US disclosed
US-20120053347-A1 COLD MENTHOL RECEPTOR-1 ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 2012-03-01 — — US disclosed
US-7897781-B2 Cold menthol receptor-1 antagonists JANSSEN PHARMACEUTICA NV (BE) 2011-03-01 — — US disclosed
EP-2029614-A2 COLD MENTHOL RECEPTOR-1 ANTAGONISTS Janssen Pharmaceutica, N.V. (BE) 2009-03-04 — — EP disclosed
US-20080287398-A1 COLD MENTHOL RECEPTOR-1 ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 2008-11-20 — — US disclosed
US-20080027029-A1 COLD MENTHOL RECEPTOR-1 ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 2008-01-31 — — US disclosed
WO-2007134107-A2 COLD MENTHOL RECEPTOR-1 ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 2007-11-22 — — WO disclosed
WO-2007017094-A1 SUBSTITUTED BENZYLOXY-PHENYLMETHYLCARBAMATE DERIVATIVES BAYER HEALTHCARE AG (DE) 2007-02-15 — — WO disclosed
WO-2007017094-A1 SUBSTITUTED BENZYLOXY-PHENYLMETHYLCARBAMATE DERIVATIVES BAYER HEALTHCARE AG (DE) 2007-02-15 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080027029-A1 COLD MENTHOL RECEPTOR-1 ANTAGONISTS TRPM8, TRPM5, TRPM7 SLC1A3 1508/4885SLC1A2 1091/4885SLC1A1 871/4885
US-20120184510-A1 COLD MENTHOL RECEPTOR-1 ANTAGONISTS TRPM8, TRPM5, TRPM7 SLC1A3 1508/4885SLC1A2 1091/4885SLC1A1 871/4885
US-20120053347-A1 COLD MENTHOL RECEPTOR-1 ANTAGONISTS TRPM8, TRPM5, TRPM7 SLC1A3 1508/4885SLC1A2 1091/4885SLC1A1 871/4885
US-20080287398-A1 COLD MENTHOL RECEPTOR-1 ANTAGONISTS TRPM8, TRPM5, TRPM7 SLC1A3 1508/4885SLC1A2 1091/4885SLC1A1 871/4885
US-20220313629-A1 TRANSIENT POTENTIAL MELASTATIN 8 (TRPM8) ANTAGONISTS AND RELATED METHODS TRPM8, TRPV1, TRPM7 SLC1A3 667/4885SLC1A2 503/4885SLC1A1 590/4885
US-20140100194-A1 COLD MENTHOL RECEPTOR-1 ANTAGONISTS TRPM8, TRPM5, TRPM7 SLC1A3 1508/4885SLC1A2 1091/4885SLC1A1 871/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.