Sugi Predict

Sugi Predict / Compounds / SCHEMBL717758

SCHEMBL717758

SCHEMBL717758

O=C(O)N(Cc1ccccc1)OCc1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.47
▸ L3MBTL1 Q9Y468 3/20 0.46
▸ KMT2A Q03164 2/20 0.46
▸ MAPK1 P28482 1/20 0.46
▸ SLC6A2 P23975 1/20 0.46
▸ SLC6A3 Q01959 1/20 0.46
▸ TDP1 Q9NUW8 1/20 0.46
▸ ALOX5 P09917 2/20 0.45
▸ PTGS1 P23219 1/20 0.45
▸ PTGS2 P35354 1/20 0.45
▸ NPC1 O15118 3/20 0.44
▸ RAB9A P51151 3/20 0.44
▸ CA12 O43570 1/20 0.44
▸ CA9 Q16790 1/20 0.44
▸ MEN1 O00255 1/20 0.43
▸ TSHR P16473 2/20 0.43
▸ LMNA P02545 1/20 0.43
▸ NPSR1 Q6W5P4 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5320045 0.87 PARP10 (0.44) ALDH1A1L3MBTL1KMT2AMAPK1SLC6A2
SCHEMBL30803699 0.85 ALDH1A1 (0.44) ALDH1A1L3MBTL1KMT2AMAPK1SLC6A2
SCHEMBL2034512 0.85 PPIB (0.51) ALDH1A1L3MBTL1KMT2AMAPK1SLC6A2
SCHEMBL27078358 0.82 ALOX5 (0.47) ALDH1A1L3MBTL1MAPK1TDP1ALOX5
SCHEMBL8550259 0.81 PLA2G10 (0.49) ALDH1A1L3MBTL1ALOX5PTGS1PTGS2
SCHEMBL3714064 0.81 MEN1 (0.51) ALDH1A1L3MBTL1KMT2ANPC1RAB9A
SCHEMBL8899616 0.80 ALDH1A1 (0.44) ALDH1A1L3MBTL1KMT2AALOX5PTGS1
SCHEMBL6866013 0.80 L3MBTL1 (0.40) ALDH1A1L3MBTL1KMT2AMAPK1SLC6A2
SCHEMBL6866010 0.80 L3MBTL1 (0.40) ALDH1A1L3MBTL1KMT2AMAPK1SLC6A2
SCHEMBL8545520 0.80 PPIB (0.51) ALDH1A1L3MBTL1KMT2AALOX5PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113677334-B Transient receptor potential MELASTATIN 8 (TRPM 8) antagonists and related methods 马歇尔大学科研协会 2024-04-09 — — CN disclosed
US-20220313629-A1 TRANSIENT POTENTIAL MELASTATIN 8 (TRPM8) ANTAGONISTS AND RELATED METHODS MARSHALL UNIVERSITY RESEARCH CORPORATION 2022-10-06 — — US disclosed
EP-3917510-A1 TRANSIENT RECEPTOR POTENTIAL MELASTATIN 8 (TRPM8) ANTAGONISTS AND RELATED METHODS Marshall University Research Corporation (US) 2021-12-08 — — EP disclosed
WO-2020160464-A1 TRANSIENT RECEPTOR POTENTIAL MELASTATIN 8 (TRPM8) ANTAGONISTS AND RELATED METHODS MARSHALL UNIVERSITY RESEARCH CORPORATION (US) 2020-08-06 — — WO disclosed
US-9090639-B2 Cold menthol receptor-1 antagonists JANSSEN PHARMACEUTICA N.V. (BE) 2015-07-28 — — US disclosed
US-20140100194-A1 COLD MENTHOL RECEPTOR-1 ANTAGONISTS JANSSEN PHARMACEUTICA, NV (BE) 2014-04-10 — — US disclosed
US-8629281-B2 Cold menthol receptor-1 antagonists JANSSEN PHARMACEUTICA, NV (BE) 2014-01-14 — — US disclosed
US-8558011-B2 Cold menthol receptor-1 antagonists JANSSEN PHARMACEUTICA, NV (BE) 2013-10-15 — — US disclosed
EP-2029614-B1 COLD MENTHOL RECEPTOR-1 ANTAGONISTS JANSSEN PHARMACEUTICA NV (BE) 2013-01-23 — — EP disclosed
US-20120184510-A1 COLD MENTHOL RECEPTOR-1 ANTAGONISTS COLBURN RAYMOND W (US) 2012-07-19 — — US disclosed
US-20120053347-A1 COLD MENTHOL RECEPTOR-1 ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 2012-03-01 — — US disclosed
US-7897781-B2 Cold menthol receptor-1 antagonists JANSSEN PHARMACEUTICA NV (BE) 2011-03-01 — — US disclosed
EP-2029614-A2 COLD MENTHOL RECEPTOR-1 ANTAGONISTS Janssen Pharmaceutica, N.V. (BE) 2009-03-04 — — EP disclosed
US-20080287398-A1 COLD MENTHOL RECEPTOR-1 ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 2008-11-20 — — US disclosed
US-20080027029-A1 COLD MENTHOL RECEPTOR-1 ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 2008-01-31 — — US disclosed
WO-2007134107-A2 COLD MENTHOL RECEPTOR-1 ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 2007-11-22 — — WO disclosed
WO-2007017094-A1 SUBSTITUTED BENZYLOXY-PHENYLMETHYLCARBAMATE DERIVATIVES BAYER HEALTHCARE AG (DE) 2007-02-15 — — WO disclosed
WO-2007017094-A1 SUBSTITUTED BENZYLOXY-PHENYLMETHYLCARBAMATE DERIVATIVES BAYER HEALTHCARE AG (DE) 2007-02-15 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080027029-A1 COLD MENTHOL RECEPTOR-1 ANTAGONISTS TRPM8, TRPM5, TRPM7 ALDH1A1 1372/4885L3MBTL1 4094/4885KMT2A 1432/4885
US-20120184510-A1 COLD MENTHOL RECEPTOR-1 ANTAGONISTS TRPM8, TRPM5, TRPM7 ALDH1A1 1372/4885L3MBTL1 4094/4885KMT2A 1432/4885
US-20120053347-A1 COLD MENTHOL RECEPTOR-1 ANTAGONISTS TRPM8, TRPM5, TRPM7 ALDH1A1 1372/4885L3MBTL1 4094/4885KMT2A 1432/4885
US-20080287398-A1 COLD MENTHOL RECEPTOR-1 ANTAGONISTS TRPM8, TRPM5, TRPM7 ALDH1A1 1372/4885L3MBTL1 4094/4885KMT2A 1432/4885
US-20220313629-A1 TRANSIENT POTENTIAL MELASTATIN 8 (TRPM8) ANTAGONISTS AND RELATED METHODS TRPM8, TRPV1, TRPM7 ALDH1A1 2851/4885L3MBTL1 2704/4885KMT2A 1511/4885
US-20140100194-A1 COLD MENTHOL RECEPTOR-1 ANTAGONISTS TRPM8, TRPM5, TRPM7 ALDH1A1 1372/4885L3MBTL1 4094/4885KMT2A 1432/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.