Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | CYP27A1 | Q02318 | 1/20 | 0.40 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1058869 | 0.88 | HTR2A (0.44) | HTR1ASLC6A4 | |
| Bromide SCHEMBL7547135 | 0.84 | HTR2A (0.42) | HTR1ASLC6A4 | |
| SCHEMBL20540008 | 0.83 | LTA4H (0.56) | HTR1ASLC6A4ALDH1A1LTA4HMAOB | |
| 1,3-Dimethoxybenzene SCHEMBL27950731 | 0.79 | MAOB (0.65) | TSHRALDH1A1TRPA1MAPK1MAOB | |
| SCHEMBL29051690 | 0.79 | CALM1 (0.53) | HTR1ASLC6A4TSHRALDH1A1MAPK1 | |
| Benzyl Bromide SCHEMBL10545816 | 0.79 | LTA4H (0.69) | TSHRALDH1A1TRPA1LTA4HKDM4E | |
| SCHEMBL2287390 | 0.78 | LTA4H (0.44) | HTR1ASLC6A4ALDH1A1LTA4HMTNR1B | |
| SCHEMBL2291189 | 0.76 | LTA4H (0.44) | TSHRALDH1A1LTA4HMAOB | |
| SCHEMBL30887370 | 0.75 | HTR1A (0.53) | HTR1ASLC6A4MAOBMTNR1AMTNR1B | |
| SCHEMBL7551792 | 0.75 | ADRA1A (0.48) | HTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1055658-B1 | Process for cis-1- 2-[4-(6-methoxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]ethyl pyrrolidine | PFIZER PROD INC (US) | 2003-03-12 | — | — | EP | disclosed |
| US-6395911-B1 | AND OTHER INTERMEDIATES TO THE OSTEOPOROSIS DRUG (-)CIS-6-PHENYL-5-(4-(2-PYRROLIDIN-1-YL-ETHOXY)-PHENYL)-5,6,7, 8-TETRAHYDRONAPHTHALENE-2-OL | PFIZER INC. | 2002-05-28 | — | — | US | disclosed |
| US-20020042524-A1 | Process for cis-1{2-[4-(6-methoxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy] ethyl}pyrrolidine | CHIU CHARLES K F (US) | 2002-04-11 | — | — | US | disclosed |
| US-6323345-B1 | BROMINATING 2-BROMO-5-METHOXY-TOLUENE TO PROVIDE 1-BROMO-2-BROMOMETHYL-4-METHOXYBENZENE; DECARBOXYLATION, REACTING WITH ETHYLENE GLYCOL; REACTING WITH N-BUTYL LITHIUM AND 4-BENZYLOXY BENZONITRILE; HYDROLYSIS, HYDROGENATION | PFIZER INC. | 2001-11-27 | — | — | US | disclosed |
| US-6232476-B1 | Intermediates in a process for cis-1-{2-[4-(6-methoxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]ethyl}pyrrolidine | PFIZER INC. | 2001-05-15 | — | — | US | disclosed |
| EP-1055658-A2 | Process for cis-1- 2-[4-(6-methoxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]ethyl pyrrolidine | Pfizer Products Inc. (US) | 2000-11-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020042524-A1 | Process for cis-1{2-[4-(6-methoxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy] ethyl}pyrrolidine | P4HA1, PAH, DNM1 | HTR1A 307/4885SLC6A4 3721/4885TSHR 2662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.