SCHEMBL1058869

SCHEMBL1058869

COc1ccc(Br)c(CBr)c1

nearest known ligand 0.44

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 2/20 0.44
HTR1A P08908 5/20 0.43
SLC6A4 P31645 5/20 0.43
IDO1 P14902 2/20 0.43
ADRA1A P35348 1/20 0.43
TAAR1 Q96RJ0 1/20 0.43
HPGD P15428 1/20 0.42
HTR2C P28335 1/20 0.41
HSD17B10 Q99714 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL7547135 0.96 HTR2A (0.42) HTR2AHTR1ASLC6A4IDO1ADRA1A
SCHEMBL2287390 0.89 LTA4H (0.44) HTR2AHTR1ASLC6A4
Benzyl Bromide SCHEMBL7181000 0.88 HTR1A (0.50) HTR1ASLC6A4
SCHEMBL7551792 0.85 ADRA1A (0.48) HTR2AHTR1ASLC6A4IDO1ADRA1A
SCHEMBL30486651 0.85 APLNR (0.46) HTR2AIDO1ADRA1ATAAR1HPGD
SCHEMBL3527192 0.85 APLNR (0.46) HTR2AIDO1ADRA1ATAAR1HPGD
SCHEMBL17330013 0.84 HTR1A (0.45) HTR2AHTR1ASLC6A4IDO1ADRA1A
SCHEMBL2001551 0.83 HSD17B10 (0.44) HTR2AHTR1ASLC6A4IDO1ADRA1A
SCHEMBL2060421 0.83 HTR2A (0.47) HTR2AIDO1ADRA1ATAAR1HSD17B10
SCHEMBL19313248 0.82 GAA (0.53) HTR2AHTR1ASLC6A4IDO1ADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 395 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117913367-A Preparation method of composite organic solvent, electrolyte and lithium-sulfur battery 东方电气集团科学技术研究院有限公司 2024-04-19 CN claimed
EP-1055658-B1 Process for cis-1- 2-[4-(6-methoxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]ethyl pyrrolidine PFIZER PROD INC (US) 2003-03-12 EP claimed
US-20020042524-A1 Process for cis-1{2-[4-(6-methoxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy] ethyl}pyrrolidine CHIU CHARLES K F (US) 2002-04-11 US claimed
US-6323345-B1 BROMINATING 2-BROMO-5-METHOXY-TOLUENE TO PROVIDE 1-BROMO-2-BROMOMETHYL-4-METHOXYBENZENE; DECARBOXYLATION, REACTING WITH ETHYLENE GLYCOL; REACTING WITH N-BUTYL LITHIUM AND 4-BENZYLOXY BENZONITRILE; HYDROLYSIS, HYDROGENATION PFIZER INC. 2001-11-27 US claimed
EP-1055658-A2 Process for cis-1- 2-[4-(6-methoxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]ethyl pyrrolidine Pfizer Products Inc. (US) 2000-11-29 EP claimed
EP-4737458-A2 PROCESS FOR MAKING CGRP RECEPTOR ANTAGONISTS Merck Sharp & Dohme LLC (US) 2026-05-06 EP disclosed
EP-4712958-A2 USE OF UROLITHIN DERIVATIVES IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS Vandria SA (CH) 2026-03-25 EP disclosed
EP-4482579-B1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH LPA RECEPTOR ACTIVITY LHOTSE BIO INC (US) 2026-02-18 EP disclosed
US-12473269-B2 Urolithin derivatives and methods of use thereof VANDRIA SA (CH) 2025-11-18 US disclosed
US-12428375-B2 Compounds and compositions for treating conditions associated with LPA receptor activity LHOTSE BIO, INC. (US) 2025-09-30 US disclosed
US-20250282782-A1 PYRAZOLOPYRAZINE COMPOUNDS AS SHP2 INHIBITORS GENZYME CORP (US) 2025-09-11 US disclosed
US-12358884-B2 Urolithin derivatives and methods of use thereof VANDRIA SA (CH) 2025-07-15 US disclosed
EP-0652875-A1 (HETERO)-ARYL KETONES DERIVATIVES WITH ANTIBACTERIAL PROPERTIES SMITHKLINE BEECHAM PLC (GB) 1995-05-17 EP disclosed
EP-0641333-A1 METHOD FOR MAKING INTERMEDIATES USEFUL IN SYNTHESIS OF RETROVIRAL PROTEASE INHIBITORS. SEARLE & CO (US) 1995-03-08 EP disclosed
WO-1994002478-A1 (HETERO)-ARYL KETONES DERIVATIVES WITH ANTIBACTERIAL PROPERTIES SMITHKLINE BEECHAM PLC (GB) 1994-02-03 WO disclosed
WO-1993023388-A1 METHOD FOR MAKING INTERMEDIATES USEFUL IN SYNTHESIS OF RETROVIRAL PROTEASE INHIBITORS G.D. SEARLE & CO. (US) 1993-11-25 WO disclosed
US-5095129-A Antiglucocorticoid, antimineralcorticoid, antiandrogen SCHERING AKTIENGESELLSCHAFT (DE) 1992-03-10 US disclosed
EP-0283428-B1 19,11-BETA-BRIDGED STEROIDS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SCHERING AKTIENGESELLSCHAFT (DE) 1991-10-30 EP disclosed
EP-0344414-A1 5-Substitued imidazo[4,5-c]pyridines G.D. Searle & Co. (US) 1989-12-06 EP disclosed
EP-0283428-A1 19,11-Beta-bridged steroids, their preparation and pharmaceutical compositions containing them SCHERING AKTIENGESELLSCHAFT (DE) 1988-09-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12358884-B2 Urolithin derivatives and methods of use thereof NLN, UQCRC2, TUFM HTR2A 3052/4885HTR1A 3534/4885SLC6A4 2096/4885
US-20020042524-A1 Process for cis-1{2-[4-(6-methoxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy] ethyl}pyrrolidine P4HA1, PAH, DNM1 HTR2A 1623/4885HTR1A 307/4885SLC6A4 3721/4885
US-20250282782-A1 PYRAZOLOPYRAZINE COMPOUNDS AS SHP2 INHIBITORS PTPN5, PTPN2, PTPRJ HTR2A 3451/4885HTR1A 4651/4885SLC6A4 4691/4885
US-12473269-B2 Urolithin derivatives and methods of use thereof NLN, UQCRC2, TUFM HTR2A 3052/4885HTR1A 3534/4885SLC6A4 2096/4885
US-12428375-B2 Compounds and compositions for treating conditions associated with LPA receptor activity LPAR2, LPAR1, LPAR6 HTR2A 635/4885HTR1A 1034/4885SLC6A4 3623/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.