Sugi Predict

Sugi Predict / Compounds / SCHEMBL718291

SCHEMBL718291

SCHEMBL718291

CC(C)C(=O)C(O[Si](C)(C)C(C)(C)C)[C@H]1O[C@@H](n2cnc3c(=O)[nH]c(N)nc32)C[C@@H]1O

nearest known ligand 0.48

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 1/20 0.48
▸ HINT1 P49773 3/20 0.43
▸ P2RY2 P41231 1/20 0.43
▸ P2RY4 P51582 1/20 0.43
▸ P2RY6 Q15077 1/20 0.43
▸ STING1 Q86WV6 3/20 0.42
▸ PDE3B Q13370 1/20 0.42
▸ PDE3A Q14432 1/20 0.42
▸ TAAR1 Q96RJ0 1/20 0.42
▸ PNP P00491 1/20 0.42
▸ NT5E P21589 1/20 0.40
▸ GSK3A P49840 2/20 0.40
▸ RPS6KA3 P51812 2/20 0.40
▸ MAPK14 Q16539 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8003285 0.92 POLB (0.51) POLBHINT1P2RY2P2RY4P2RY6
SCHEMBL717632 0.89 POLB (0.41) POLBHINT1P2RY2P2RY4P2RY6
SCHEMBL717274 0.86 KDM4E (0.41) POLBHINT1P2RY2P2RY4P2RY6
SCHEMBL15953158 0.85 POLB (0.50) POLBHINT1P2RY2P2RY4P2RY6
SCHEMBL9059968 0.83 TAAR1 (0.49) POLBHINT1P2RY2P2RY4P2RY6
SCHEMBL888190 0.82 POLB (0.43) POLBHINT1STING1PDE3BPDE3A
SCHEMBL5355319 0.81 POLB (0.47) POLBHINT1P2RY2P2RY4P2RY6
SCHEMBL3779342 0.81 POLB (0.55) POLBHINT1P2RY2P2RY4P2RY6
SCHEMBL6835146 0.81 TYMP (0.45) POLBHINT1P2RY2P2RY4P2RY6
SCHEMBL30712246 0.80 POLB (0.58) POLBP2RY2P2RY4P2RY6STING1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11940413-B2 Methods and devices for sequencing nucleic acids in smaller batches IsoPlexis Corporation (US) 2024-03-26 — — US disclosed
US-20240076731-A1 METHODS AND COMPOSITIONS FOR INCORPORATING NUCLEOTIDES QIAGEN SCIENCES, LLC 2024-03-07 — — US disclosed
US-20240060128-A1 METHODS AND COMPOSITIONS FOR INCORPORATING NUCLEOTIDES QIAGEN WALTHAM, INC. 2024-02-22 — — US disclosed
US-20230407384-A1 METHODS AND COMPOSITIONS FOR INCORPORATING NUCLEOTIDES QIAGEN WALTHAM, INC. 2023-12-21 — — US disclosed
US-11548910-B2 Oligonucleotide production method NISSAN CHEMICAL CORPORATION (JP) 2023-01-10 — — US disclosed
US-11390858-B2 Modified template-independent enzymes for polydeoxynucleotide synthesis Molecular Assemblies, Inc. (US) 2022-07-19 — — US disclosed
US-20210230686-A1 METHODS AND COMPOSITIONS FOR INCORPORATING NUCLEOTIDES IsoPlexis Corporation 2021-07-29 — — US disclosed
US-20210231609-A1 METHODS AND DEVICES FOR SEQUENCING NUCLEIC ACIDS IN SMALLER BATCHES IsoPlexis Corporation 2021-07-29 — — US disclosed
US-11035823-B2 Methods and devices for sequencing nucleic acids in smaller batches QIAGEN SCIENCES, LLC (US) 2021-06-15 — — US disclosed
US-11001887-B2 Methods and compositions for incorporating nucleotides QIAGEN SCIENCES, LLC (US) 2021-05-11 — — US disclosed
US-20130301888-A1 Methods And Compositions For Base Calling Nucleic Acids IsoPlexis Corporation 2013-11-14 — — US disclosed
US-8481259-B2 Methods and devices for sequencing nucleic acids in smaller batches INTELLIGENT BIO-SYSTEMS, INC. (US) 2013-07-09 — — US disclosed
US-20130137091-A1 Methods And Compositions For Incorporating Nucleotides INTELLIGENT BIO-SYSTEMS, INC. 2013-05-30 — — US disclosed
US-20120052489-A1 METHODS AND COMPOSITIONS FOR SEQUENCING NUCLEIC ACIDS USING CHARGE INTELLIGENT BIO-SYSTEMS, INC. 2012-03-01 — — US disclosed
US-20110124054-A1 Methods And Compositions For Inhibiting Undesired Cleaving Of Labels INTELLIGENT BIO-SYSTEMS, INC. 2011-05-26 — — US disclosed
US-20100330569-A1 Hydroxymethyl Linkers For Labeling Nucleotides INTELLIGENT BIO-SYSTEMS, INC. 2010-12-30 — — US disclosed
US-20100323350-A1 Methods And Devices For Sequencing Nucleic Acids In Smaller Batches INTELLIGENT BIOSYSTEMS, INC. 2010-12-23 — — US disclosed
US-20100159531-A1 Methods And Solutions For Inhibiting Undesired Cleaving Of Labels INTELLIGENT BIO-SYSTEMS, INC. 2010-06-24 — — US disclosed
US-20100063743-A1 Methods And Compositions For Base Calling Nucleic Acids INTELLIGENT BIO-SYSTEMS, INC. 2010-03-11 — — US disclosed
US-20100035253-A1 Methods And Compositions For Incorporating Nucleotides INTELLIGENT BIO-SYSTEMS, INC. 2010-02-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210230686-A1 METHODS AND COMPOSITIONS FOR INCORPORATING NUCLEOTIDES NT5C2, NOP2, NT5C3B POLB 44/4885HINT1 32/4885P2RY2 361/4885
US-11548910-B2 Oligonucleotide production method RNGTT, OSGEP, PHAX POLB 37/4885HINT1 36/4885P2RY2 1859/4885
US-20240076731-A1 METHODS AND COMPOSITIONS FOR INCORPORATING NUCLEOTIDES NT5C2, NOP2, NT5C3B POLB 44/4885HINT1 32/4885P2RY2 361/4885
US-11001887-B2 Methods and compositions for incorporating nucleotides NT5C2, NOP2, NT5C3B POLB 44/4885HINT1 32/4885P2RY2 361/4885
US-20230407384-A1 METHODS AND COMPOSITIONS FOR INCORPORATING NUCLEOTIDES NT5C2, NOP2, NT5C3B POLB 44/4885HINT1 32/4885P2RY2 361/4885
US-20240060128-A1 METHODS AND COMPOSITIONS FOR INCORPORATING NUCLEOTIDES NT5C2, NOP2, NT5C3B POLB 44/4885HINT1 32/4885P2RY2 361/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.