Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | PPM1B | O75688 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1578042 | 1.00 | MAPT (0.39) | MAPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL1577514 | 1.00 | MAPT (0.39) | MAPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL1578216 | 1.00 | MAPT (0.39) | MAPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL1577775 | 0.86 | PPM1B (0.39) | ALDH1A1LMNAPPM1BPTPN1PPP1CC | |
| SCHEMBL3691417 | 0.85 | ALDH1A1 (0.47) | MAPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL1577887 | 0.83 | ALDH1A1 (0.42) | ALDH1A1LMNAL3MBTL1HPGD | |
| SCHEMBL16409442 | 0.83 | LMNA (0.41) | MAPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL1578269 | 0.82 | EPHX2 (0.43) | — | |
| SCHEMBL8462991 | 0.82 | ALDH1A1 (0.40) | MAPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL18900188 | 0.82 | MAPT (0.38) | MAPTCYP3A4CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-10080298-A | — | — | None | — | — | JP | disclosed |
| JP-8245500-A | — | — | None | — | — | JP | disclosed |
| CN-110483272-B | Novel method for asymmetric synthesis of (1S,2S) -2-fluorocyclopropanecarboxylic acid by catalysis of chiral rhodium catalyst | 广州康瑞泰药业有限公司 | 2022-09-27 | — | — | CN | disclosed |
| US-10385000-B2 | Method for synthesizing 2-fluorocyclopropane carboxylic acid | CHEN-STONE (GUANGZHOU) CO., LTD. (CN) | 2019-08-20 | — | — | US | disclosed |
| EP-2651899-B1 | SUBSTITUTED 6,6-FUSED NITROGENOUS HETEROCYCLIC COMPOUNDS AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2017-05-31 | — | — | EP | disclosed |
| EP-2651899-B1 | SUBSTITUTED 6,6-FUSED NITROGENOUS HETEROCYCLIC COMPOUNDS AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2017-05-31 | — | — | EP | disclosed |
| US-20160060262-A1 | Substituted 6,6-Fused Nitrogenous Heterocyclic Compounds and Uses Thereof | GENENTECH, INC. (US) | 2016-03-03 | — | — | US | disclosed |
| US-20160060262-A1 | Substituted 6,6-Fused Nitrogenous Heterocyclic Compounds and Uses Thereof | GENENTECH, INC. (US) | 2016-03-03 | — | — | US | disclosed |
| US-20160060262-A1 | Substituted 6,6-Fused Nitrogenous Heterocyclic Compounds and Uses Thereof | GENENTECH, INC. (US) | 2016-03-03 | — | — | US | disclosed |
| US-9206175-B2 | Substituted 6,6-fused nitrogenous heterocyclic compounds and uses thereof | GENENTECH, INC. (US) | 2015-12-08 | — | — | US | disclosed |
| US-6596898-B2 | Making a 2-fluoro-2-chlorocyclopropanecarboxylic acid derivative stereoselectively in high yield by reacting a diazoacetic acid derivative with 1-fluoro-1-chloroethylene using metal catalyst having chiral ligands | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2003-07-22 | — | — | US | disclosed |
| US-20010051750-A1 | PROCESS FOR PREPARING HALOGENATED CYCLOPROPANE DERIVATIVES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2001-12-13 | — | — | US | disclosed |
| EP-0858992-B1 | PROCESS FOR PRODUCING HALOGENATED CYCLOPROPANE DERIVATIVES | DAIICHI SEIYAKU CO (JP) | 2001-12-12 | — | — | EP | disclosed |
| US-6130350-A | Process for producing 2-fluorine-1-cyclopropane carboxylic acid derivatives by reductive dehalogenation | BAYER AKTIENGESELLSCHAFT (DE) | 2000-10-10 | — | — | US | disclosed |
| EP-0712831-B1 | SELECTIVE DEHALOGENATION METHOD | DAIICHI SEIYAKU CO (JP) | 1999-11-03 | — | — | EP | disclosed |
| EP-0858992-A1 | PROCESS FOR PRODUCING HALOGENATED CYCLOPROPANE DERIVATIVES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1998-08-19 | — | — | EP | disclosed |
| US-5780669-A | Selective dehalogenation process | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1998-07-14 | — | — | US | disclosed |
| JP-H1080298-A | PRODUCTION OF OPTICALLY ACTIVE SUBSTANCE OF 2-HALO-2-FLUOROCYCLOPROPANECARBOXYLIC ACID | SUMITOMO CHEM CO LTD | 1998-03-31 | — | — | JP | disclosed |
| JP-H08245500-A | PRODUCTION OF 2-FLUOROCYCLOPROPANECARBOXYLIC ACIDS | SUMITOMO CHEM CO LTD | 1996-09-24 | — | — | JP | disclosed |
| EP-0712831-A1 | SELECTIVE DEHALOGENATION METHOD | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1996-05-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10385000-B2 | Method for synthesizing 2-fluorocyclopropane carboxylic acid | FOSB, FDPS, PFAS | MAPT 4383/4885CYP3A4 767/4885CYP2D6 1203/4885 |
| US-20160060262-A1 | Substituted 6,6-Fused Nitrogenous Heterocyclic Compounds and Uses Thereof | XDH, CYP2B6, COX6B1 | MAPT 4200/4885CYP3A4 27/4885CYP2D6 4/4885 |
| US-20010051750-A1 | PROCESS FOR PREPARING HALOGENATED CYCLOPROPANE DERIVATIVES | CYP2F1, CYP4F2, CYP4F8 | MAPT 4557/4885CYP3A4 44/4885CYP2D6 167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.