Nornicotine

Nornicotine

SCHEMBL7197292

c1cncc([C@H]2CCCN2)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 9/20 1.00
CHRNA4 P43681 9/20 1.00
CHRNA7 P36544 7/20 1.00
CYP2A6 P11509 4/20 0.90
MEN1 O00255 2/20 0.90
CYP2D6 P10635 2/20 0.90
CYP2C19 P33261 2/20 0.90
KMT2A Q03164 2/20 0.90
POLB P06746 1/20 0.90
SMN1; SMN2 Q16637 1/20 0.90
CYP1A2 P05177 1/20 0.90
CYP2C9 P11712 1/20 0.90
CYP11B2 P19099 1/20 0.55
ALDH1A1 P00352 2/20 0.46
CHRNB4 P30926 2/20 0.46
CHRNA3 P32297 2/20 0.46
CHRNA2 Q15822 2/20 0.46
LMNA P02545 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
HTR3E A5X5Y0 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nornicotine SCHEMBL13090363 1.00 CHRNB2 (1.00) CHRNB2CHRNA4CHRNA7CYP2A6MEN1
Nornicotine SCHEMBL29571520 1.00 CHRNB2 (1.00) CHRNB2CHRNA4CHRNA7CYP2A6MEN1
Nornicotine SCHEMBL158145 1.00 CHRNB2 (1.00) CHRNB2CHRNA4CHRNA7CYP2A6MEN1
Nornicotine SCHEMBL158146 1.00 CHRNB2 (1.00) CHRNB2CHRNA4CHRNA7CYP2A6MEN1
Nornicotine SCHEMBL29362147 1.00 CHRNB2 (1.00) CHRNB2CHRNA4CHRNA7CYP2A6MEN1
Nornicotine SCHEMBL30866559 1.00 CHRNB2 (1.00) CHRNB2CHRNA4CHRNA7CYP2A6MEN1
Nornicotine SCHEMBL932560 0.98 CHRNB2 (0.96) CHRNB2CHRNA4CHRNA7CYP2A6MEN1
Dl-Anabasine SCHEMBL117530 0.95 CHRNB2 (1.00) CHRNB2CHRNA4CHRNA7CYP2A6MEN1
Dl-Anabasine SCHEMBL30835558 0.95 CHRNB2 (1.00) CHRNB2CHRNA4CHRNA7CYP2A6MEN1
Anabasine SCHEMBL29634446 0.95 CHRNB2 (1.00) CHRNB2CHRNA4CHRNA7CYP2A6MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116354841-B Method for synthesizing formamide by catalyzing lower amine and carbon dioxide by polymer-based catalyst 中国科学院兰州化学物理研究所 2024-06-14 CN claimed
CN-116354841-A Method for synthesizing formamide by catalyzing lower amine and carbon dioxide by polymer-based catalyst 中国科学院兰州化学物理研究所 2023-06-30 CN claimed
EP-1284976-A2 DIAZABICYCLIC CENTRAL NERVOUS SYSTEM ACTIVE AGENTS Abbott Laboratories (US) 2003-02-26 EP claimed
WO-2001081347-A2 DIAZABICYCLIC CENTRAL NERVOUS SYSTEM ACTIVE AGENTS ABBOTT LABORATORIES (US) 2001-11-01 WO claimed
EP-4638433-A1 NAMPT MODULATORS Cytokinetics, Inc. (US) 2025-10-29 EP disclosed
US-20240279215-A1 NAMPT MODULATORS CYTOKINETICS, INCORPORATED 2024-08-22 US disclosed
WO-2024137981-A1 NAMPT MODULATORS CYTOKINETICS, INCORPORATED (US) 2024-06-27 WO disclosed
CN-116354841-B Method for synthesizing formamide by catalyzing lower amine and carbon dioxide by polymer-based catalyst 中国科学院兰州化学物理研究所 2024-06-14 CN disclosed
US-20230348369-A1 NAMPT MODULATORS CYTOKINETICS, INC. 2023-11-02 US disclosed
US-20230301341-A1 COMPOSITIONS AND METHODS FOR SUBLINGUAL DELIVERY OF NICOTINE Poviva Corp. (US) 2023-09-28 US disclosed
US-20230301341-A1 COMPOSITIONS AND METHODS FOR SUBLINGUAL DELIVERY OF NICOTINE Poviva Corp. (US) 2023-09-28 US disclosed
US-11700875-B1 Compositions and methods for sublingual delivery of nicotine Poviva Corp. (US) 2023-07-18 US disclosed
WO-2011111875-A1 N-ACYL CYCLIC AMINE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2011-09-15 WO disclosed
US-20110112130-A1 Opioid-Nornicotine Codrugs Combinations for Pain Management UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 2011-05-12 US disclosed
US-20100216847-A1 NORNICOTINE FOR THE TREATMENT OF PAIN UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 2010-08-26 US disclosed
US-20100216847-A1 NORNICOTINE FOR THE TREATMENT OF PAIN UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 2010-08-26 US disclosed
US-20100048605-A1 SYNERGISTIC EFFECTS OF COMBINATIONS OF NORNICOTINE AND OPIOIDS FOR THE TREATMENT OF PAIN UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 2010-02-25 US disclosed
US-20100048605-A1 SYNERGISTIC EFFECTS OF COMBINATIONS OF NORNICOTINE AND OPIOIDS FOR THE TREATMENT OF PAIN UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 2010-02-25 US disclosed
WO-2009121018-A2 OPIOID-NORNICOTINE CODRUGS FOR PAIN MANAGEMENT UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 2009-10-01 WO disclosed
WO-2008063556-A2 NORNICOTINE FOR THE TREATMENT OF PAIN UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 2008-05-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100048605-A1 SYNERGISTIC EFFECTS OF COMBINATIONS OF NORNICOTINE AND OPIOIDS FOR THE TREATMENT OF PAIN OPRL1, OPRM1, OPRD1 CHRNB2 79/4885CHRNA4 208/4885CHRNA7 151/4885
US-20100216847-A1 NORNICOTINE FOR THE TREATMENT OF PAIN OPRL1, NAPRT, OPRM1 CHRNB2 106/4885CHRNA4 303/4885CHRNA7 183/4885
US-20230348369-A1 NAMPT MODULATORS NAMPT, NNT, NAPRT CHRNB2 2750/4885CHRNA4 2524/4885CHRNA7 2813/4885
US-20240279215-A1 NAMPT MODULATORS NAMPT, SIRT1, NNT CHRNB2 2854/4885CHRNA4 2804/4885CHRNA7 2605/4885
US-20110112130-A1 Opioid-Nornicotine Codrugs Combinations for Pain Management OPRM1, OPRL1, OPRK1 CHRNB2 91/4885CHRNA4 51/4885CHRNA7 75/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.