Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | MMP16 | P51512 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168330 | 0.80 | AKR1C3 (0.44) | LMNAALDH1A1KMT2A | |
| SCHEMBL7202738 | 0.73 | PTGS2 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7202476 | 0.71 | CNR1 (0.40) | PTGS2MAPTKMT2A | |
| SCHEMBL7203324 | 0.71 | PTGS2 (0.45) | PTGS2MAPTKMT2A | |
| SCHEMBL2208256 | 0.67 | MMP2 (0.62) | LMNAPTGS2BCAT2MMP1MMP2 | |
| SCHEMBL7241953 | 0.64 | KMT2A (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL20769655 | 0.64 | ALDH1A1 (0.51) | LMNAALDH1A1 | |
| SCHEMBL2000060 | 0.63 | BAZ2B (0.38) | LMNAPTGS2ALDH1A1MAPTKMT2A | |
| SCHEMBL11569102 | 0.62 | AKR1C3 (0.65) | LMNAPTGS2MAPTKMT2A | |
| SCHEMBL25139928 | 0.62 | PSEN1 (0.45) | LMNAPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |